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From innate to adaptive immune responses in contact hypersensitivity Stefan F. Martin and Thilo Jakob Allergy Research Group, Department of Dermatology, Purpose of review University Medical Center Freiburg, Freiburg, Germany To summarize recent findings that highlight the importance of the innate inflammatory Correspondence to Stefan F. Martin, PhD, Professor of immune responses in contact dermatitis and their role for the adaptive T-cell response Immunobiology, Allergy Research Group, Department to contact allergens. Implications for anti-inflammatory therapy based on recent of Dermatology, University Medical Center Freiburg, Hauptstrasse 7, D-79104 Freiburg, Germany reports are discussed. Tel: +49 761 270 6738; fax: +49 761 270 6655; Recent findings e-mail: stefan.martin@uniklinik-freiburg.de Allergic contact dermatitis is studied widely in the mouse model. Recent work has identified an important role of innate pattern recognition receptors and innate immune Current Opinion in Allergy and Clinical cells in contact hypersensitivity. The role of skin dendritic cells has been studied with Immunology 2008, 8:289–293 novel approaches for in-vivo depletion. New findings were made in the field of anti- inflammatory therapy either by uncovering new aspects of pathomechanisms or by the use of drugs that target different elements of the inflammatory cascade. Summary Inflammation is a pivotal element of allergic
Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health
Published: Aug 1, 2008
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