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Frequent Expression of Glypican-3 in Merkel Cell Carcinoma An Immunohistochemical Study of 55 Cases

Frequent Expression of Glypican-3 in Merkel Cell Carcinoma An Immunohistochemical Study of 55 Cases RESEARCH ARTICLE Frequent Expression of Glypican-3 in Merkel Cell Carcinoma An Immunohistochemical Study of 55 Cases Huiying He, MD, PhD,*w Weigang Fang, MD, PhD,w Xiyong Liu, MD, PhD,z Lawrence M. Weiss, MD,* and Peiguo G. Chu, MD, PhD* erkel cell carcinoma (MCC) is a rare neuroendo- Abstract: The pathologic diagnosis of Merkel cell carcinoma Mcrine carcinoma with an aggressive biologic beha- (MCC) is mainly based on routine morphology and a vior usually occurring in the sun-damaged skin of elderly 1–3 characteristic cytokeratin 20 (CK20) immunohistochemical patients. MCC is composed of monotonous small staining pattern. However, about 10% to 15% of MCCs are round tumor cells that possess ovoid nuclei with evenly reportedly CK20 negative and about 10% to 20% of MCCs distributed chromatin, and inconspicuous nucleoli. The have only focal CK20 positivity. We aimed to study glypican-3 cytoplasm is typically scanty and amphophilic. Histolo- (GPC3) expression in MCC and to compare it with CK20 gically, MCC shares many histologic features with other expression in MCC. Immunohistochemical expression of GPC-3, small round cell (undifferentiated) tumors, including CK20, and CD23 were studied in 55 cases of MCC and 21 small cell carcinoma of the lung, Wilms tumor, neuro- cases of noncutaneous http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Frequent Expression of Glypican-3 in Merkel Cell Carcinoma An Immunohistochemical Study of 55 Cases

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ISSN
1541-2016
DOI
10.1097/PAI.0b013e31817b67d1
pmid
18813128
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Frequent Expression of Glypican-3 in Merkel Cell Carcinoma An Immunohistochemical Study of 55 Cases Huiying He, MD, PhD,*w Weigang Fang, MD, PhD,w Xiyong Liu, MD, PhD,z Lawrence M. Weiss, MD,* and Peiguo G. Chu, MD, PhD* erkel cell carcinoma (MCC) is a rare neuroendo- Abstract: The pathologic diagnosis of Merkel cell carcinoma Mcrine carcinoma with an aggressive biologic beha- (MCC) is mainly based on routine morphology and a vior usually occurring in the sun-damaged skin of elderly 1–3 characteristic cytokeratin 20 (CK20) immunohistochemical patients. MCC is composed of monotonous small staining pattern. However, about 10% to 15% of MCCs are round tumor cells that possess ovoid nuclei with evenly reportedly CK20 negative and about 10% to 20% of MCCs distributed chromatin, and inconspicuous nucleoli. The have only focal CK20 positivity. We aimed to study glypican-3 cytoplasm is typically scanty and amphophilic. Histolo- (GPC3) expression in MCC and to compare it with CK20 gically, MCC shares many histologic features with other expression in MCC. Immunohistochemical expression of GPC-3, small round cell (undifferentiated) tumors, including CK20, and CD23 were studied in 55 cases of MCC and 21 small cell carcinoma of the lung, Wilms tumor, neuro- cases of noncutaneous

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Jan 1, 2009

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