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Foxp3 +

Foxp3 + ORIGINAL ARTICLE Foxp3 Regulatory T Cells and Natural Killer Cells Distinctly Infiltrate Primary Tumors and Draining Lymph Nodes in Pulmonary Adenocarcinoma Thomas Schneider, MD,* Silvia Kimpfler, PhD,† Arne Warth, MD,‡ Philipp A. Schnabel, MD, PhD,‡ Hendrik Dienemann, MD, PhD,* Dirk Schadendorf, MD, PhD,§ Hans Hoffmann, MD, PhD,* and Viktor Umansky, MD, PhD† ung cancer is the leading cause of cancer death worldwide, Introduction: Regulatory T cells (Tregs) can play a key role in Lwith a growing incidence in both developed and develop- suppressing T-cell-mediated immunity in patients with cancer. In this ing countries. Because the prognosis remains poor when study, the immune cell composition of the lung tissue and draining lymph using conventional cancer therapy methods, the need for new, nodes from patients with non-small cell lung cancer was analyzed. effective adjuvant therapies is apparent. Immunotherapy, in Methods: Samples (solid tumor, tumor border, and tumor-free lung particular an activation of tumor-infiltrating immune cells, tissue, as well as intrapulmonal N1 and mediastinal N2 lymph may offer a promising approach. Nevertheless, the success of nodes) from 30 patients subjected to curative resection were ana- such treatment has been limited up to now, probably due to lyzed by immunohistochemistry and flow cytometry. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Foxp3 +

Umansky, Viktor
Journal of Thoracic Oncology , Volume 6 (3) – Mar 1, 2011
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ISSN
1556-0864
DOI
10.1097/JTO.0b013e31820b80ca
pmid
21258248
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Foxp3 Regulatory T Cells and Natural Killer Cells Distinctly Infiltrate Primary Tumors and Draining Lymph Nodes in Pulmonary Adenocarcinoma Thomas Schneider, MD,* Silvia Kimpfler, PhD,† Arne Warth, MD,‡ Philipp A. Schnabel, MD, PhD,‡ Hendrik Dienemann, MD, PhD,* Dirk Schadendorf, MD, PhD,§ Hans Hoffmann, MD, PhD,* and Viktor Umansky, MD, PhD† ung cancer is the leading cause of cancer death worldwide, Introduction: Regulatory T cells (Tregs) can play a key role in Lwith a growing incidence in both developed and develop- suppressing T-cell-mediated immunity in patients with cancer. In this ing countries. Because the prognosis remains poor when study, the immune cell composition of the lung tissue and draining lymph using conventional cancer therapy methods, the need for new, nodes from patients with non-small cell lung cancer was analyzed. effective adjuvant therapies is apparent. Immunotherapy, in Methods: Samples (solid tumor, tumor border, and tumor-free lung particular an activation of tumor-infiltrating immune cells, tissue, as well as intrapulmonal N1 and mediastinal N2 lymph may offer a promising approach. Nevertheless, the success of nodes) from 30 patients subjected to curative resection were ana- such treatment has been limited up to now, probably due to lyzed by immunohistochemistry and flow cytometry.

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Mar 1, 2011

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