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ORIGINAL ARTICLE Four-Year Results of Low-Dose CT Screening and Nodule Management in the ITALUNG Trial Andrea Lopes Pegna, MD* Giulia Picozzi, MD,† Fabio Falaschi, MD,‡ Laura Carrozzi, MD,§ Massimo Falchini, MD,║ Francesca Maria Carozzi, MD,¶ Francesco Pistelli, MD, § Camilla Comin, MD,# Annalisa Deliperi, MD,‡ Michela Grazzini, MD,** Florio Innocenti, MD,** Cristina Maddau, MD,¶ Alessandra Vella, MD, PhD,†† Luca Vaggelli, MD,║║ Eugenio Paci, MD, PhD,¶¶ and Mario Mascalchi, MD, PhD║ for the ITALUNG Study Research Group LDCT screening and management protocol in the active arm of the Introduction: Recruitment and nodule management are critical ITALUNG trial. issues of lung cancer screening with low-dose computed tomog- Methods: Three thousand two hundred six smokers or former smok- raphy (LDCT). We report subjects’ compliance and results of ers invited by mail were randomized to receive four annual LDCT (n = 1613) or usual care (n = 1593). Management protocol included *Pneumonology Department, Careggi Hospital, Florence, Italy; †Radiodiagnostic Unit, 18 follow-up LDCT, 2-[ F]fluoro-2-deoxy-D glucose positron emis- Institute for Oncological Study and Prevention, Florence, Italy; ‡2nd Radiology sion tomography (FDG-PET), and CT-guided fine-needle aspiration Department, University Hospital of Pisa, Italy; §Cardiopulmonary Department, biopsy (FNAB). University Hospital, Pisa, Italy; ║Radiodiagnostic Section, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy; Results: One thousand
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Jul 1, 2013
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