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Follicular Dendritic Cell Immunohistochemical Markers in Angioimmunoblastic T-Cell Lymphoma

Follicular Dendritic Cell Immunohistochemical Markers in Angioimmunoblastic T-Cell Lymphoma RESEARCH ARTICLE Follicular Dendritic Cell Immunohistochemical Markers in Angioimmunoblastic T-Cell Lymphoma Megan L. Troxell, MD, PhD,* Erich J. Schwartz, MD, PhD,* Matt van de Rijn, MD, PhD,* Douglas T. Ross, MD, PhD,† Roger A. Warnke, MD,* John P. Higgins, MD,* and Yasodha Natkunam, MD, PhD* and WHO classification systems to include cases previously Abstract: Angioimmunoblastic T-cell lymphoma is characterized considered AILD-like T-cell lymphoma (angioimmunoblastic by a paracortical proliferation of medium to large neoplastic T cells, lymphadenopathy with dysproteinemia), and accounts for ap- 1–4 often with clear cytoplasm, in a background of arborizing high endo- proximately 2% of non-Hodgkin lymphomas. The diagno- thelial venules, many surrounded by follicular dendritic cells (FDCs). sis of angioimmunoblastic T-cell lymphoma is problematic, IHC staining may be applied to highlight these extrafollicular FDCs, and other entities, including atypical T-zone hyperplasia, traditionally using CD21, or CD23. Several alternative FDC markers Castleman’s disease, peripheral T-cell lymphoma NOS, T-cell have been described, including CNA.42, cystatin A/acid cysteine pro- and histiocyte-rich large B-cell lymphoma, and Hodgkin lym- 2,3 teinase inhibitor (ACPI, involved in antigen presentation), and fascin phoma, enter the differential. Morphologic features of angio- (an actin binding protein). The authors stained a collection of 45 immunoblastic T-cell lymphoma http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Follicular Dendritic Cell Immunohistochemical Markers in Angioimmunoblastic T-Cell Lymphoma

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References (35)

Copyright
Copyright © 2005 by Lippincott Williams & Wilkins
ISSN
1062-3345
eISSN
1533-4058
DOI
10.1097/01.pai.0000173053.45296.51
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Follicular Dendritic Cell Immunohistochemical Markers in Angioimmunoblastic T-Cell Lymphoma Megan L. Troxell, MD, PhD,* Erich J. Schwartz, MD, PhD,* Matt van de Rijn, MD, PhD,* Douglas T. Ross, MD, PhD,† Roger A. Warnke, MD,* John P. Higgins, MD,* and Yasodha Natkunam, MD, PhD* and WHO classification systems to include cases previously Abstract: Angioimmunoblastic T-cell lymphoma is characterized considered AILD-like T-cell lymphoma (angioimmunoblastic by a paracortical proliferation of medium to large neoplastic T cells, lymphadenopathy with dysproteinemia), and accounts for ap- 1–4 often with clear cytoplasm, in a background of arborizing high endo- proximately 2% of non-Hodgkin lymphomas. The diagno- thelial venules, many surrounded by follicular dendritic cells (FDCs). sis of angioimmunoblastic T-cell lymphoma is problematic, IHC staining may be applied to highlight these extrafollicular FDCs, and other entities, including atypical T-zone hyperplasia, traditionally using CD21, or CD23. Several alternative FDC markers Castleman’s disease, peripheral T-cell lymphoma NOS, T-cell have been described, including CNA.42, cystatin A/acid cysteine pro- and histiocyte-rich large B-cell lymphoma, and Hodgkin lym- 2,3 teinase inhibitor (ACPI, involved in antigen presentation), and fascin phoma, enter the differential. Morphologic features of angio- (an actin binding protein). The authors stained a collection of 45 immunoblastic T-cell lymphoma

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Dec 1, 2005

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