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Feasibility of Optical Coherence Tomography in Children With Kawasaki Disease and Pediatric Heart Transplant Recipients

Feasibility of Optical Coherence Tomography in Children With Kawasaki Disease and Pediatric Heart... Intravascular Imaging Feasibility of Optical Coherence Tomography in Children With Kawasaki Disease and Pediatric Heart Transplant Recipients Kevin C. Harris, MD, MHSc; Anas Manouzi, MD; Anthony Y. Fung, MBBS; Astrid De Souza, MSc; Hiram G. Bezerra, MD, PhD; James E. Potts, PhD; Martin C.K. Hosking, MD Background—Optical coherence tomography (OCT) is a high-resolution intravascular imaging technique used in adults. We tested the hypothesis that OCT could identify coronary abnormalities not seen by angiography in children with a history of Kawasaki disease (KD) and pediatric heart transplant (TX) recipients. Methods and Results—Patients with KD and TX recipients were evaluated between December 2012 and October 2013 with angiography and OCT (Ilumien System, LightLabs, St Jude Medical, Westford, MA). Modifications were made to the adult OCT protocol to adapt this technique for children. Serial cross-sectional area measurements of the lumen, intima, and media were made. Entire imaging data were analyzed for the presence of qualitative changes. Seventeen children were evaluated (5 patients with KD; 12 TX recipients). In patients with KD, angiography was normal. However, OCT imaging revealed that significant vessel wall abnormalities were present in all children including intimal thickening (intima/lumen cross-sectional area ratio>0.4), loss of the normal layered structure of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Cardiovascular Imaging Wolters Kluwer Health

Feasibility of Optical Coherence Tomography in Children With Kawasaki Disease and Pediatric Heart Transplant Recipients

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Copyright
© 2014 American Heart Association, Inc.
ISSN
1941-9651
eISSN
1942-0080
DOI
10.1161/CIRCIMAGING.113.001764
pmid
24874056
Publisher site
See Article on Publisher Site

Abstract

Intravascular Imaging Feasibility of Optical Coherence Tomography in Children With Kawasaki Disease and Pediatric Heart Transplant Recipients Kevin C. Harris, MD, MHSc; Anas Manouzi, MD; Anthony Y. Fung, MBBS; Astrid De Souza, MSc; Hiram G. Bezerra, MD, PhD; James E. Potts, PhD; Martin C.K. Hosking, MD Background—Optical coherence tomography (OCT) is a high-resolution intravascular imaging technique used in adults. We tested the hypothesis that OCT could identify coronary abnormalities not seen by angiography in children with a history of Kawasaki disease (KD) and pediatric heart transplant (TX) recipients. Methods and Results—Patients with KD and TX recipients were evaluated between December 2012 and October 2013 with angiography and OCT (Ilumien System, LightLabs, St Jude Medical, Westford, MA). Modifications were made to the adult OCT protocol to adapt this technique for children. Serial cross-sectional area measurements of the lumen, intima, and media were made. Entire imaging data were analyzed for the presence of qualitative changes. Seventeen children were evaluated (5 patients with KD; 12 TX recipients). In patients with KD, angiography was normal. However, OCT imaging revealed that significant vessel wall abnormalities were present in all children including intimal thickening (intima/lumen cross-sectional area ratio>0.4), loss of the normal layered structure of

Journal

Circulation: Cardiovascular ImagingWolters Kluwer Health

Published: Jul 1, 2014

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