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FDG PET/CT in a Case of Lynch Syndrome With Synchronous Inverted Urothelial Papilloma of the Bladder, Urothelial Carcinoma of the Ureter, and Jejunal Adenocarcinoma

FDG PET/CT in a Case of Lynch Syndrome With Synchronous Inverted Urothelial Papilloma of the... Abstract A 64-year-old man was referred because of the right ureteral obstruction. CT urography showed an intraluminal enhancing mass in the right midureter and an enhancing nodule in the bladder wall. FDG PET/CT showed increased FDG uptake of the ureteral mass and an unexpected hypermetabolic lesion in the jejunum. The patient underwent transurethral resection of the bladder tumor, right laparoscopic nephroureterectomy, and partial enterectomy. Inverted urothelial papilloma of the bladder, high-grade urothelial carcinoma of the right ureter, and jejunal adenocarcinoma were confirmed by histopathology. Genetic testing of the jejunal adenocarcinoma revealed MSH2 germline mutation, confirming the diagnosis of Lynch syndrome. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Nuclear Medicine Wolters Kluwer Health

FDG PET/CT in a Case of Lynch Syndrome With Synchronous Inverted Urothelial Papilloma of the Bladder, Urothelial Carcinoma of the Ureter, and Jejunal Adenocarcinoma

Zhao, Qian; Dong, Aisheng; Wang, Yang
Clinical Nuclear Medicine , Volume 47 (1) – Jan 25, 2022
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Publisher
Wolters Kluwer Health
Copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
0363-9762
eISSN
1536-0229
DOI
10.1097/rlu.0000000000003779
Publisher site
See Article on Publisher Site

Abstract

Abstract A 64-year-old man was referred because of the right ureteral obstruction. CT urography showed an intraluminal enhancing mass in the right midureter and an enhancing nodule in the bladder wall. FDG PET/CT showed increased FDG uptake of the ureteral mass and an unexpected hypermetabolic lesion in the jejunum. The patient underwent transurethral resection of the bladder tumor, right laparoscopic nephroureterectomy, and partial enterectomy. Inverted urothelial papilloma of the bladder, high-grade urothelial carcinoma of the right ureter, and jejunal adenocarcinoma were confirmed by histopathology. Genetic testing of the jejunal adenocarcinoma revealed MSH2 germline mutation, confirming the diagnosis of Lynch syndrome.

Journal

Clinical Nuclear Medicine – Wolters Kluwer Health

Published: Jan 25, 2022

References

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    Potenta, SE; D’Agostino, R; Sternberg, KM
  • Lynch syndrome: genomics update and imaging review
    Cox, VL; Saeed Bamashmos, AA; Foo, WC
  • Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in lynch syndrome
    Bonadona, V; Bonaïti, B; Olschwang, S
  • Lynch syndrome in urologic malignancies—what does the urologist need to know?
    Goldberg, H; Wallis, CJD; Klaassen, Z
  • Small-bowel cancer in lynch syndrome: is it time for surveillance?
    Koornstra, JJ; Kleibeuker, JH; Vasen, HF
  • Double small bowel cancers leading to the diagnosis of lynch syndrome with germline MSH6 mutation in an elderly patient
    Ohwada, S; Yamashita, K; Kazama, T
  • Prolonged treatment response to pembrolizumab in a patient with pretreated metastatic colon cancer and lynch syndrome
    Keating, M; Giscombe, L; Tannous, T
  • Lynch syndrome associated colon adenocarcinoma resembling lymphoma on fluoro-deoxyglucose-positron emission tomography/computed tomography
    Aparici, CM; Win, AZ