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Expression of Proto-Oncogene cFMS Protein in Lung, Breast, and Ovarian Cancers

Expression of Proto-Oncogene cFMS Protein in Lung, Breast, and Ovarian Cancers RESEARCH ARTICLE Expression of Proto-Oncogene cFMS Protein in Lung, Breast, and Ovarian Cancers Satoko Kakiuchi-Kiyota, BS, MS, PhD,* Patrick B. Lappin, DVM, PhD, DACVP,w Catherine Heintz, BS,* Paul W. Brown, BS, MA, PhD,z Flavia O. Pinho, BS, MS,* Anne M. Ryan, DVM, PhD, DACVP,* and Nagappan Mathialagan, BS, MS, PhD* diverse tumor therapeutic options and presents an attractive Abstract: We performed immunohistochemistry for macrophage target for drug development. colony-stimulating factor 1 receptor (also known as c-fms proto- Key Words: macrophage colony-stimulating factor 1 receptor oncogene product) on tissue microarrays of human nontumor (cFMS), stromal fibroblasts, carcinomas, adenocarcinomas, lung, pulmonary squamous cell carcinomas (SCC) and adeno- glucocorticoid signaling carcinomas (ADC), and breast and ovarian carcinomas using a commercially available anti-cFMS antibody. The specificity of (Appl Immunohistochem Mol Morphol 2014;22:188–199) the antibody was validated by Western blot and mass spec- trometry analysis. Staining of cFMS was restricted to stromal fibroblasts in pulmonary SCC and ADC specimens and was not -fms proto-oncogene product, cFMS is the receptor identified in tumor epithelium or epithelium and stromal cells of cfor macrophage colony-stimulating factor 1 (CSF-1), nontumor lung. Evaluation of pulmonary SCC (n = 63) and and consists of a highly glycosylated extracellular ligand- ADC http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Expression of Proto-Oncogene cFMS Protein in Lung, Breast, and Ovarian Cancers

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Copyright
Copyright © 2013 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0b013e31828e7104
pmid
23702648
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Expression of Proto-Oncogene cFMS Protein in Lung, Breast, and Ovarian Cancers Satoko Kakiuchi-Kiyota, BS, MS, PhD,* Patrick B. Lappin, DVM, PhD, DACVP,w Catherine Heintz, BS,* Paul W. Brown, BS, MA, PhD,z Flavia O. Pinho, BS, MS,* Anne M. Ryan, DVM, PhD, DACVP,* and Nagappan Mathialagan, BS, MS, PhD* diverse tumor therapeutic options and presents an attractive Abstract: We performed immunohistochemistry for macrophage target for drug development. colony-stimulating factor 1 receptor (also known as c-fms proto- Key Words: macrophage colony-stimulating factor 1 receptor oncogene product) on tissue microarrays of human nontumor (cFMS), stromal fibroblasts, carcinomas, adenocarcinomas, lung, pulmonary squamous cell carcinomas (SCC) and adeno- glucocorticoid signaling carcinomas (ADC), and breast and ovarian carcinomas using a commercially available anti-cFMS antibody. The specificity of (Appl Immunohistochem Mol Morphol 2014;22:188–199) the antibody was validated by Western blot and mass spec- trometry analysis. Staining of cFMS was restricted to stromal fibroblasts in pulmonary SCC and ADC specimens and was not -fms proto-oncogene product, cFMS is the receptor identified in tumor epithelium or epithelium and stromal cells of cfor macrophage colony-stimulating factor 1 (CSF-1), nontumor lung. Evaluation of pulmonary SCC (n = 63) and and consists of a highly glycosylated extracellular ligand- ADC

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Mar 1, 2014

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