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Expression of Proteinase-activated Receptor-2 in the Esophageal Mucosa of Gastroesophageal Reflux Disease Patients A Histomorphologic and Immunohistochemical Study

Expression of Proteinase-activated Receptor-2 in the Esophageal Mucosa of Gastroesophageal Reflux... RESEARCH ARTICLE Expression of Proteinase-activated Receptor-2 in the Esophageal Mucosa of Gastroesophageal Reflux Disease Patients: A Histomorphologic and Immunohistochemical Study Dalia M. Abd El-Rehim, PhD,* Hanaa K. Fath El-Bab, MD,w and Enas M. Kamal, MDw general population. Patients with GERD have a sig- Abstract: Data are limited regarding the role of proteinase- nificantly impaired quality of life due to recurrent symp- activated receptor-2 (PAR-2) in the esophageal mucosa in gas- toms and increased risk for complications such as Barrett’s troesophageal reflux disease (GERD) patients. Our aim was to 1 esophagus and adenocarcinoma of the esophagus. GERD study PAR-2 expression and its relationship with different comprises 2 distinct clinical entities, the nonerosive reflux GERD-related clinical and pathologic parameters. Histo- disease (NERD), which is detected in patients having morphologic alterations in eosophageal mucosa in nonerosive symptoms without endoscopically visible mucosal damage reflux disease (NERD) and erosive reflux disease (ERD) were and the erosive reflux disease (ERD), which is identifiable also, evaluated. Endoscopic biopsies of the esophageal mucosa in patients with esophageal erosions. Both variants should were obtained from 94 GERD patients and 20 participants for be considered as different disease states and evaluated in- histopathologic analysis and PAR-2 immunohistochemical dependently for http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Expression of Proteinase-activated Receptor-2 in the Esophageal Mucosa of Gastroesophageal Reflux Disease Patients A Histomorphologic and Immunohistochemical Study

Applied Immunohistochemistry & Molecular Morphology , Volume Publish Ahead of Print – Sep 1, 2014

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Copyright
Copyright © 2014 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0000000000000130
pmid
25265427
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Expression of Proteinase-activated Receptor-2 in the Esophageal Mucosa of Gastroesophageal Reflux Disease Patients: A Histomorphologic and Immunohistochemical Study Dalia M. Abd El-Rehim, PhD,* Hanaa K. Fath El-Bab, MD,w and Enas M. Kamal, MDw general population. Patients with GERD have a sig- Abstract: Data are limited regarding the role of proteinase- nificantly impaired quality of life due to recurrent symp- activated receptor-2 (PAR-2) in the esophageal mucosa in gas- toms and increased risk for complications such as Barrett’s troesophageal reflux disease (GERD) patients. Our aim was to 1 esophagus and adenocarcinoma of the esophagus. GERD study PAR-2 expression and its relationship with different comprises 2 distinct clinical entities, the nonerosive reflux GERD-related clinical and pathologic parameters. Histo- disease (NERD), which is detected in patients having morphologic alterations in eosophageal mucosa in nonerosive symptoms without endoscopically visible mucosal damage reflux disease (NERD) and erosive reflux disease (ERD) were and the erosive reflux disease (ERD), which is identifiable also, evaluated. Endoscopic biopsies of the esophageal mucosa in patients with esophageal erosions. Both variants should were obtained from 94 GERD patients and 20 participants for be considered as different disease states and evaluated in- histopathologic analysis and PAR-2 immunohistochemical dependently for

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Sep 1, 2014

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