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RESEARCH ARTICLE Expression of OCT4 Transcription Factor in Cutaneous Neoplasia Terrence M. Katona, DO,* Steven D. Billings, MD,* Rodolfo Montironi, MD,w Antonio Lopez-Beltran, MD,z and Liang Cheng, MD* primordial germ cells, and several neoplasms including 1–10 Abstract: The OCT4 transcription factor is a marker of seminoma, dysgerminoma, and embryonal carcinoma. pluripotency and is present in embryonic stem cells, primordial It is critical in the establishment and maintenance of 6,11–13 germ cells, and several neoplasms including seminoma, dysger- pluripotency. Recently, immunohistochemical ex- minoma, and embryonal carcinoma. Recently, immunohisto- pression of OCT 4 protein has been described in rare chemical expression of OCT4 protein has been described in the basal cells within human and canine epidermis. In cells within the basal layer of normal human and canine addition, OCT4 immunopositive cells have been identified epidermis. We have examined a series of basal cell carcinomas within the hair follicle bulge of human scalp. The latter and adnexal tumors of related histiogenesis, in an effort to finding was thought to indicate the presence of stem cells corroborate the above findings and to assess for expression of which may contribute to cutaneous plasticity. OCT4 protein in neoplasia of the infundibulo-apocrine-sebac- To the best of
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Dec 1, 2007
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