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Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Expression of Maspin and Glutathionine-S-Transferase-p in Normal Human Prostate and Prostatic Carcinomas Eva Lovric´, MD,* Zoran Gatalica, MD, DSc,w Eduardo Eyzaguirre, MD,z and Boz˘o Krus˘lin, MD, PhDy Key Words: Maspin, glutathionine-S-transferase-p, prostate Background: Maspin and glutathionine-S-transferase-p (GST-p) cancer are both involved in tumor suppression activity. Maspin (Appl Immunohistochem Mol Morphol 2010;18:429–432) expression functions as an inhibitor of tumor progression preventing the local invasion and metastatic spread of prostate cancer cells. GST-p has an essential role in the inactivation of xenobiotic agents and protection from oxidative stress and in resistance to chemotherapy. Furthermore, a recent experi- rostatic adenocarcinoma is the most common cancer mental evidence indicated that maspin and GST-p may directly Pin males, and its etiology is largely unknown. Chronic interact in the protection of the prostatic cells from oxydative inflammation is linked to the development of premalig- damage. nant changes in the prostate through the cellular oxida- tive damage and epigenetic abnormalities, in particular Design: Maspin and GST-p expression were assessed in needle altered DNA methylation. Inflammatory processes may core and transurethral resection prostatic biopsies from 42 induce DNA mutations in cells through oxidative stress patients (34 with carcinoma,
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Oct 1, 2010
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