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RESEARCH ARTICLE Expression of Elafin in Fallopian Tubes of Ectopic Pregnancies Is Reduced Melina Grudzinski, Pharm, PhD,* Daniele G. Fuhrich, Bsc,w and Ricardo F. Savaris, MD, MSc, PhD*w lopian tubes, however, its expression is constant in- Abstract: Elafin is a natural antimicrobial molecule member of dependently of the phase of menstrual cycle. the antileukoproteinase (Trappin) family that is normally ex- Recently, our group has published that women with pressed in the mucosa of human fallopian tubes and neutrophils. hydrosalpinx have a reduced expression of elafin either in Ectopic pregnancy is a condition in which neutrophil influx is 8 9 the endometrium or in the fallopian tubes. Damaged present. Current data on elafin expression on fallopian tubes fallopian tubes due to previous infection have a higher with ectopic pregnancy do not differentiate the expression of 10 risk for tubal pregnancy. Tubal pregnancy is a con- elafin in these 2 compartments. The objective of this study was 11 dition that affects 1% to 2% of all pregnancies. The to analyze the protein expression of elafin on epithelial mucosa current literature evaluating the relationship between of fallopian tubes with and without ectopic pregnancy using elafin and ectopic pregnancy is scant. After a
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: May 1, 2015
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