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Expression of EGFR in Gastric Stromal Tumors: A Clinicopathologic Study

Expression of EGFR in Gastric Stromal Tumors: A Clinicopathologic Study Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Expression of EGFR in Gastric Stromal Tumors A Clinicopathologic Study Xiaofei Qiu, MD, PhD*w and Elizabeth Montgomery, MD* embryonal rhabdomyosarcoma, synovial sarcoma, leio- Abstract: Epidermal growth factor receptor (EGFR) plays myosarcoma, liposarcoma, osteosarcoma, chondrosar- an important role in cancer biology and offers a promising coma, malignant peripheral nerve sheath tumor, and 3–8 molecular therapeutic target. The expression profile of EGFR in malignant fibrous histiocytoma, variably express gastrointestinal stromal tumors (GISTs) is derived from a EGFR, EGFR/ERBB1, ERBB2, ERBB3, and ERBB4; limited number of small series samples and case reports. We nevertheless, to our knowledge, the expression of these evaluated the involvement of EGFR in human gastric GISTs. receptors in gastric gastrointestinal stromal tumors Tissue microarray sections representing 33 gastric GISTs with (GISTs) has so far been reported only by Cai et al, known follow-up were surveyed by immunohistochemistry, who evaluated 9 patients with GIST, and by Lanzafame using antibodies specific for EGFR. Expression of EGFR was et al, who reported a single patient with gastric GIST, identified in 8/33 (24.2%) cases, and tended to be present in and by Lopes, who studied 27 patients with gastric tumors of smaller size http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Expression of EGFR in Gastric Stromal Tumors: A Clinicopathologic Study

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References (24)

Publisher
Wolters Kluwer Health
ISSN
1541-2016
DOI
10.1097/PAI.0b013e318159b877
Publisher site
See Article on Publisher Site

Abstract

Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Expression of EGFR in Gastric Stromal Tumors A Clinicopathologic Study Xiaofei Qiu, MD, PhD*w and Elizabeth Montgomery, MD* embryonal rhabdomyosarcoma, synovial sarcoma, leio- Abstract: Epidermal growth factor receptor (EGFR) plays myosarcoma, liposarcoma, osteosarcoma, chondrosar- an important role in cancer biology and offers a promising coma, malignant peripheral nerve sheath tumor, and 3–8 molecular therapeutic target. The expression profile of EGFR in malignant fibrous histiocytoma, variably express gastrointestinal stromal tumors (GISTs) is derived from a EGFR, EGFR/ERBB1, ERBB2, ERBB3, and ERBB4; limited number of small series samples and case reports. We nevertheless, to our knowledge, the expression of these evaluated the involvement of EGFR in human gastric GISTs. receptors in gastric gastrointestinal stromal tumors Tissue microarray sections representing 33 gastric GISTs with (GISTs) has so far been reported only by Cai et al, known follow-up were surveyed by immunohistochemistry, who evaluated 9 patients with GIST, and by Lanzafame using antibodies specific for EGFR. Expression of EGFR was et al, who reported a single patient with gastric GIST, identified in 8/33 (24.2%) cases, and tended to be present in and by Lopes, who studied 27 patients with gastric tumors of smaller size

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Jul 1, 2008

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