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Expression of Activation-induced Cytidine Deaminase in Malignant Lymphomas Infiltrating the Bone Marrow

Expression of Activation-induced Cytidine Deaminase in Malignant Lymphomas Infiltrating the Bone... RESEARCH ARTICLE Expression of Activation-induced Cytidine Deaminase in Malignant Lymphomas Infiltrating the Bone Marrow Knut Engels, MD,* Berit Jungnickel, PhD,w Stephanie Tobollik, PhD,w Martin-Leo Hansmann, MD, PhD,* Susanne Kriener, MD,* and Klaus Willenbrock, MD, PhD* introduces mainly point mutations in Ig variable region Abstract: Somatic hypermutation of immunoglobulin genes and genes, and class switch recombination (CSR) occurs. class switch recombination are pivotal processes in the germinal This process of clonal proliferation combined with DNA center (GC) reaction and have been implicated in the develop- modification, including DNA double strand breaks, is ment of malignant B-cell lymphoma. Both processes require the error prone. Chromosomal translocations of oncogenes enzyme activation-induced cytidine deaminase (AID). Expres- into the Ig gene locus occur and SHM may also target 7,8 sion of AID is largely restricted to GC B cells and B cells that genes outside the Ig gene locus. undergo class switch recombination outside the GC. AID is also Consequently, most B-cell lymphomas derive from expressed in many B-cell lymphomas. This study investigates the GC B cells and memory B cells and frequently display expression of AID of malignant lymphomas infiltrating the bone characteristic chromosomal translocations involving Ig marrow. Bone marrow trephines (n = http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Expression of Activation-induced Cytidine Deaminase in Malignant Lymphomas Infiltrating the Bone Marrow

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ISSN
1541-2016
DOI
10.1097/PAI.0b013e3181758ce5
pmid
18776814
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Expression of Activation-induced Cytidine Deaminase in Malignant Lymphomas Infiltrating the Bone Marrow Knut Engels, MD,* Berit Jungnickel, PhD,w Stephanie Tobollik, PhD,w Martin-Leo Hansmann, MD, PhD,* Susanne Kriener, MD,* and Klaus Willenbrock, MD, PhD* introduces mainly point mutations in Ig variable region Abstract: Somatic hypermutation of immunoglobulin genes and genes, and class switch recombination (CSR) occurs. class switch recombination are pivotal processes in the germinal This process of clonal proliferation combined with DNA center (GC) reaction and have been implicated in the develop- modification, including DNA double strand breaks, is ment of malignant B-cell lymphoma. Both processes require the error prone. Chromosomal translocations of oncogenes enzyme activation-induced cytidine deaminase (AID). Expres- into the Ig gene locus occur and SHM may also target 7,8 sion of AID is largely restricted to GC B cells and B cells that genes outside the Ig gene locus. undergo class switch recombination outside the GC. AID is also Consequently, most B-cell lymphomas derive from expressed in many B-cell lymphomas. This study investigates the GC B cells and memory B cells and frequently display expression of AID of malignant lymphomas infiltrating the bone characteristic chromosomal translocations involving Ig marrow. Bone marrow trephines (n =

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Dec 1, 2008

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