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Exposure–response in occupational allergy

Exposure–response in occupational allergy Exposure – response in occupational allergy Meinir G. Jones Department of Occupational and Environmental Purpose of review Medicine, Imperial College, London, UK This review examines the relationship between exposure to workplace allergens and the Correspondence to Meinir G. Jones, Department of risk of developing occupational allergy. Occupational and Environmental Medicine, Imperial Recent findings College, 1B Manresa Road, London SW3 6LR, UK Tel: +44 20 7351 8355; Evidence suggests that the risk of developing occupational allergy increases with e-mail: meinir.jones@imperial.ac.uk allergen exposure; however, with some occupational allergens, this exposure – response relationship is more complex. In laboratory animal workers, the risk of developing Current Opinion in Allergy and Clinical occupational allergy increases with exposure, except at high allergen exposure when Immunology 2008, 8:110–114 there is a reduction in sensitization. This attenuation of specific immunoglobulin E antibody is associated with increased specific immunoglobulin G antibodies, which are likely to play a protective role, leading to a form of natural tolerance. Exposure – response relationships are also very dependent on the genetic susceptibility of the individual. The interaction between genes, occupational allergens and other cofactors in the environment, such as endotoxin, are also important risk factors in the development of sensitization and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Allergy and Clinical Immunology Wolters Kluwer Health

Exposure–response in occupational allergy

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References (32)

ISSN
1528-4050
eISSN
1473-6322
DOI
10.1097/ACI.0b013e3282f4b5f1
pmid
18317017
Publisher site
See Article on Publisher Site

Abstract

Exposure – response in occupational allergy Meinir G. Jones Department of Occupational and Environmental Purpose of review Medicine, Imperial College, London, UK This review examines the relationship between exposure to workplace allergens and the Correspondence to Meinir G. Jones, Department of risk of developing occupational allergy. Occupational and Environmental Medicine, Imperial Recent findings College, 1B Manresa Road, London SW3 6LR, UK Tel: +44 20 7351 8355; Evidence suggests that the risk of developing occupational allergy increases with e-mail: meinir.jones@imperial.ac.uk allergen exposure; however, with some occupational allergens, this exposure – response relationship is more complex. In laboratory animal workers, the risk of developing Current Opinion in Allergy and Clinical occupational allergy increases with exposure, except at high allergen exposure when Immunology 2008, 8:110–114 there is a reduction in sensitization. This attenuation of specific immunoglobulin E antibody is associated with increased specific immunoglobulin G antibodies, which are likely to play a protective role, leading to a form of natural tolerance. Exposure – response relationships are also very dependent on the genetic susceptibility of the individual. The interaction between genes, occupational allergens and other cofactors in the environment, such as endotoxin, are also important risk factors in the development of sensitization and

Journal

Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health

Published: Apr 1, 2008

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