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Evaluation of Putative Renal Cell Carcinoma Markers PAX-2, PAX-8, and hKIM-1 in Germ Cell Tumors: A Tissue Microarray Study of 100 Cases

Evaluation of Putative Renal Cell Carcinoma Markers PAX-2, PAX-8, and hKIM-1 in Germ Cell Tumors:... Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Evaluation of Putative Renal Cell Carcinoma Markers PAX-2, PAX-8, and hKIM-1 in Germ Cell Tumors: A Tissue Microarray Study of 100 Cases Ankur R. Sangoi, MD,*w Jesse K. McKenney, MD,*z James D. Brooks, MD,z Joseph V. Bonventre, MD, PhD,y and John P. Higgins, MD* 2,3 (PAX-8) and yolk sac tumors (PAX-2, PAX-8, hKIM-1); Abstract: In a subset of cases, metastatic renal cell carcinoma however, a thorough characterization in a large series of can demonstrate significant morphologic overlap with germ cell germ cell tumors has not been previously reported. neoplasms, making accurate diagnosis challenging. In such cases, immunohistochemistry is often used as an adjunct diag- nostic tool. Expression of the putative renal cell carcinoma MATERIALS AND METHODS markers PAX-2, PAX-8, and hKIM-1 has been reported in a A tissue microarray composed of 100 randomly small series of certain germ cell tumors, raising doubt about distributed germ cell tumors [including choriocarcinoma their specificity for renal cell carcinoma. To further characterize (1), embryonal carcinoma (21), intratubular germ cell these markers, we evaluated PAX-2, PAX-8, and hKIM-1 neoplasia unclassified (2), seminoma (61), spermatocytic staining in 100 germ cell tumors using tissue microarrays. PAX- seminoma http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Evaluation of Putative Renal Cell Carcinoma Markers PAX-2, PAX-8, and hKIM-1 in Germ Cell Tumors: A Tissue Microarray Study of 100 Cases

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Publisher
Wolters Kluwer Health
ISSN
1541-2016
DOI
10.1097/PAI.0b013e31824bb404
Publisher site
See Article on Publisher Site

Abstract

Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Evaluation of Putative Renal Cell Carcinoma Markers PAX-2, PAX-8, and hKIM-1 in Germ Cell Tumors: A Tissue Microarray Study of 100 Cases Ankur R. Sangoi, MD,*w Jesse K. McKenney, MD,*z James D. Brooks, MD,z Joseph V. Bonventre, MD, PhD,y and John P. Higgins, MD* 2,3 (PAX-8) and yolk sac tumors (PAX-2, PAX-8, hKIM-1); Abstract: In a subset of cases, metastatic renal cell carcinoma however, a thorough characterization in a large series of can demonstrate significant morphologic overlap with germ cell germ cell tumors has not been previously reported. neoplasms, making accurate diagnosis challenging. In such cases, immunohistochemistry is often used as an adjunct diag- nostic tool. Expression of the putative renal cell carcinoma MATERIALS AND METHODS markers PAX-2, PAX-8, and hKIM-1 has been reported in a A tissue microarray composed of 100 randomly small series of certain germ cell tumors, raising doubt about distributed germ cell tumors [including choriocarcinoma their specificity for renal cell carcinoma. To further characterize (1), embryonal carcinoma (21), intratubular germ cell these markers, we evaluated PAX-2, PAX-8, and hKIM-1 neoplasia unclassified (2), seminoma (61), spermatocytic staining in 100 germ cell tumors using tissue microarrays. PAX- seminoma

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Oct 1, 2012

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