Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Evaluation of Putative Renal Cell Carcinoma Markers PAX-2, PAX-8, and hKIM-1 in Germ Cell Tumors: A Tissue Microarray Study of 100 Cases Ankur R. Sangoi, MD,*w Jesse K. McKenney, MD,*z James D. Brooks, MD,z Joseph V. Bonventre, MD, PhD,y and John P. Higgins, MD* 2,3 (PAX-8) and yolk sac tumors (PAX-2, PAX-8, hKIM-1); Abstract: In a subset of cases, metastatic renal cell carcinoma however, a thorough characterization in a large series of can demonstrate significant morphologic overlap with germ cell germ cell tumors has not been previously reported. neoplasms, making accurate diagnosis challenging. In such cases, immunohistochemistry is often used as an adjunct diag- nostic tool. Expression of the putative renal cell carcinoma MATERIALS AND METHODS markers PAX-2, PAX-8, and hKIM-1 has been reported in a A tissue microarray composed of 100 randomly small series of certain germ cell tumors, raising doubt about distributed germ cell tumors [including choriocarcinoma their specificity for renal cell carcinoma. To further characterize (1), embryonal carcinoma (21), intratubular germ cell these markers, we evaluated PAX-2, PAX-8, and hKIM-1 neoplasia unclassified (2), seminoma (61), spermatocytic staining in 100 germ cell tumors using tissue microarrays. PAX- seminoma
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Oct 1, 2012
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.