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ORIGINAL ARTICLE Evaluation of Glutathione Metabolic Genes on Outcomes in Advanced Non-small Cell Lung Cancer Patients after Initial Treatment with Platinum-Based Chemotherapy An NCCTG-97-24-51 Based Study Ping Yang, MD, PhD,* Sumithra J. Mandrekar, PhD,* Shauna H. Hillman, MS,* Katie L. Allen Ziegler, BS,* Zhifu Sun, MD, MS,* Jason A. Wampfler, BS,* Julie M. Cunningham, PhD,* Jeff A. Sloan, PhD,* Alex A. Adjei, MD, PhD,*† Edith Perez, MD,* and James R. Jett, MD* and measure the effects of these genes in chemotherapeutic regi- Introduction: We evaluated the role of glutathione-related geno- mens, drug toxicities, disease progression, and QOL are critical. types on overall survival, time to progression, adverse events, and Key Words: Gluthathione metabolic genes, Non small cell lung quality of life (QOL) in stage IIIB/IV non-small cell lung cancer cancer, Platinum-based chemotherapy. patients who were stable or responding from initial treatment with platinum-based chemotherapy and subsequently randomized to re- (J Thorac Oncol. 2009;4: 479–485) ceive daily oral carboxyaminoimidazole or a placebo. Methods: Of the 186 total patients, 113 had initial treatment with platinum therapy and DNA samples of whom 46 also had QOL data. latinum-based compounds remain the most commonly These samples were analyzed using six polymorphic DNA markers
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Apr 1, 2009
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