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Estrogen Receptor β in Breast Cancer: Associations Between ER Hormonal Receptors, and Other Prognostic Biomarkers

Estrogen Receptor β in Breast Cancer: Associations Between ER Hormonal Receptors, and... The estrogen receptor (ER)-β isoform has been recently identified to be distinct from ERα isoform and regulates separate sets of genes, and can exert opposite signaling functions depending on the ligand and response elements. Previous studies of ERβ have been at the mRNA level and few by immunohistochemistry, and the results are inconsistent. In this study the authors compared expression of ERβ with those of other prognostic biomarkers by immunohistochemistry on tissue microarray slides, and with morphologic parameters on 147 cases of primary breast cancer. Immunoreactivity of more than 10% of cancer cells was considered to be positive. Associations between categoric variables were analyzed using the χ http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Estrogen Receptor β in Breast Cancer: Associations Between ER Hormonal Receptors, and Other Prognostic Biomarkers

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Copyright
Copyright © 2005 by Lippincott Williams & Wilkins
ISSN
1541-2016

Abstract

The estrogen receptor (ER)-β isoform has been recently identified to be distinct from ERα isoform and regulates separate sets of genes, and can exert opposite signaling functions depending on the ligand and response elements. Previous studies of ERβ have been at the mRNA level and few by immunohistochemistry, and the results are inconsistent. In this study the authors compared expression of ERβ with those of other prognostic biomarkers by immunohistochemistry on tissue microarray slides, and with morphologic parameters on 147 cases of primary breast cancer. Immunoreactivity of more than 10% of cancer cells was considered to be positive. Associations between categoric variables were analyzed using the χ

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Mar 1, 2005

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