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Estrogen Receptor Beta (ERβ) in Endometrial Simple Hyperplasia and Endometrioid Carcinoma

Estrogen Receptor Beta (ERβ) in Endometrial Simple Hyperplasia and Endometrioid Carcinoma RESEARCH ARTICLE Estrogen Receptor Beta (ERb) in Endometrial Simple Hyperplasia and Endometrioid Carcinoma Dimple Chakravarty, PhD,* Radhika Srinivasan, MD, PhD,* Sujata Ghosh, PhD,w Arvind Rajwanshi, MD, FRC (Path),* and Sarala Gopalan, MD, PhDz he endometrium is an exquisitely hormone-sensitive Aims: The aim of this study was to analyze the expression of Ttissue and a principal target of estrogen and proges- estrogen receptor (ER) b in endometrioid carcinoma in terone, which act through their cognate receptors namely, comparison to non-neoplastic endometrium. estrogen receptor alpha (ERa), estrogen receptor beta (ERb) and the progesterone receptor (PR). ERb was Methods: Fifty-seven histopathologically confirmed non-neo- cloned in 1996 and subsequently characterized by its plastic endometria (22 proliferative phase, 15 secretory phase, distinct properties. Both ER subtypes are highly and 20 simple hyperplasia without atypia), and 26 cases of conserved at the DNA (96%) and ligand-binding (60%) endometrioid carcinoma were studied. The ERb/ERa transcript domains, with reduced homology between other parts of ratio was determined by semiquantitative reverse transcription- the molecule, especially, at the N-terminus. Although the polymerase chain reaction. The receptor protein expression was DNA-binding domain is extremely well conserved (96%), evaluated by immunohistochemistry using the Allred Scoring ERb and ERa may activate different http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Estrogen Receptor Beta (ERβ) in Endometrial Simple Hyperplasia and Endometrioid Carcinoma

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ISSN
1541-2016
DOI
10.1097/PAI.0b013e31816755a9
pmid
18931615
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Estrogen Receptor Beta (ERb) in Endometrial Simple Hyperplasia and Endometrioid Carcinoma Dimple Chakravarty, PhD,* Radhika Srinivasan, MD, PhD,* Sujata Ghosh, PhD,w Arvind Rajwanshi, MD, FRC (Path),* and Sarala Gopalan, MD, PhDz he endometrium is an exquisitely hormone-sensitive Aims: The aim of this study was to analyze the expression of Ttissue and a principal target of estrogen and proges- estrogen receptor (ER) b in endometrioid carcinoma in terone, which act through their cognate receptors namely, comparison to non-neoplastic endometrium. estrogen receptor alpha (ERa), estrogen receptor beta (ERb) and the progesterone receptor (PR). ERb was Methods: Fifty-seven histopathologically confirmed non-neo- cloned in 1996 and subsequently characterized by its plastic endometria (22 proliferative phase, 15 secretory phase, distinct properties. Both ER subtypes are highly and 20 simple hyperplasia without atypia), and 26 cases of conserved at the DNA (96%) and ligand-binding (60%) endometrioid carcinoma were studied. The ERb/ERa transcript domains, with reduced homology between other parts of ratio was determined by semiquantitative reverse transcription- the molecule, especially, at the N-terminus. Although the polymerase chain reaction. The receptor protein expression was DNA-binding domain is extremely well conserved (96%), evaluated by immunohistochemistry using the Allred Scoring ERb and ERa may activate different

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Dec 1, 2008

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