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Estrogen and Progesterone Receptor Expression is not Always Specific for Mammary and Gynecologic Carcinomas A Tissue Microarray and Pooled Literature Review Study

Estrogen and Progesterone Receptor Expression is not Always Specific for Mammary and Gynecologic... RESEARCH ARTICLE Estrogen and Progesterone Receptor Expression is not Always Specific for Mammary and Gynecologic Carcinomas A Tissue Microarray and Pooled Literature Review Study Shi Wei, MD, PhD,* Nasser Said-Al-Naief, DDS, MS,* and Omar Hameed, MBChB*w z (Appl Immunohistochem Mol Morphol 2009;17:393–402) Abstract: Given their frequent expression in breast and gynecologic carcinomas, the National Comprehensive Cancer Network has recommended that the immunohistochemical s the immunohistochemical expression of estrogen expression of estrogen (ER) and/or progesterone (PR) receptors A(ER) and progesterone (PR) receptors in breast in a carcinoma of unknown primary can be used to support a carcinoma (BC) predicts response to hormonal therapy, breast or gynecologic origin. Several reports in the literature, their expression is routinely evaluated in all cases of however, have described such expression in a variable propor- primary BC. In addition, given that one or both are tion of nonmammary and nongynecologic carcinomas. The aim expressed in 70% to 95% of BCs, and in a significant of this study was to systematically evaluate the immunohisto- proportion of ovarian and endometrial carcinomas, it chemical expression of ER and PR on tissue microarray sections has been recommended that immunohistochemical ex- representing 348 nonbreast or gynecologic and nongynecologic pression of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Estrogen and Progesterone Receptor Expression is not Always Specific for Mammary and Gynecologic Carcinomas A Tissue Microarray and Pooled Literature Review Study

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ISSN
1541-2016
DOI
10.1097/PAI.0b013e31819faa07
pmid
19417624
Publisher site
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Abstract

RESEARCH ARTICLE Estrogen and Progesterone Receptor Expression is not Always Specific for Mammary and Gynecologic Carcinomas A Tissue Microarray and Pooled Literature Review Study Shi Wei, MD, PhD,* Nasser Said-Al-Naief, DDS, MS,* and Omar Hameed, MBChB*w z (Appl Immunohistochem Mol Morphol 2009;17:393–402) Abstract: Given their frequent expression in breast and gynecologic carcinomas, the National Comprehensive Cancer Network has recommended that the immunohistochemical s the immunohistochemical expression of estrogen expression of estrogen (ER) and/or progesterone (PR) receptors A(ER) and progesterone (PR) receptors in breast in a carcinoma of unknown primary can be used to support a carcinoma (BC) predicts response to hormonal therapy, breast or gynecologic origin. Several reports in the literature, their expression is routinely evaluated in all cases of however, have described such expression in a variable propor- primary BC. In addition, given that one or both are tion of nonmammary and nongynecologic carcinomas. The aim expressed in 70% to 95% of BCs, and in a significant of this study was to systematically evaluate the immunohisto- proportion of ovarian and endometrial carcinomas, it chemical expression of ER and PR on tissue microarray sections has been recommended that immunohistochemical ex- representing 348 nonbreast or gynecologic and nongynecologic pression of

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Oct 1, 2009

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