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G. Sozzi, D. Conte, L. Mariani, S. Vullo, L. Roz, C. Lombardo, M. Pierotti, L. Tavecchio (2001)
Analysis of circulating tumor DNA in plasma at diagnosis and during follow-up of lung cancer patients.Cancer research, 61 12
A. Mutirangura, W. Pornthanakasem, A. Theamboonlers, V. Sriuranpong, Prasert Lertsanguansinchi, S. Yenrudi, N. Voravud, P. Supiyaphun, Y. Poovorawan (1998)
Epstein-Barr viral DNA in serum of patients with nasopharyngeal carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research, 4 3
M. Stroun, Philippe Anker, P. Maurice, Jacqueline Lyautey, C. Lederrey, M. Beljanski (1989)
Neoplastic characteristics of the DNA found in the plasma of cancer patients.Oncology, 46 5
K. Chan, S. Leung, S. Yeung, A. Chan, Y. Lo (2008)
Persistent Aberrations in Circulating DNA Integrity after Radiotherapy Are Associated with Poor Prognosis in Nasopharyngeal Carcinoma PatientsClinical Cancer Research, 14
Sozzi (2003)
Quantification of free circulating DNA as a diagnostic marker in lung cancerJ Clin Oncol, 21
P. Anker, H. Mulcahy, M. Stroun (2003)
Circulating nucleic acids in plasma and serum as a noninvasive investigation for cancer: Time for large‐scale clinical studies?International Journal of Cancer, 103
M. Esteller, M. Sanchez-Cespedes, R. Rosell, D. Sidransky, S. Baylin, J. Herman (1999)
Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.Cancer research, 59 1
A. Sandler, R. Gray, M. Perry, J. Brahmer, J. Schiller, A. Dowlati, R. Lilenbaum, David Johnson (2006)
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer.The New England journal of medicine, 355 24
F. Liu, J. Killian, M. Yang, R. Walker, J. Hong, M. Zhang, S. Davis, Y. Zhang, M. Hussain, S. Xi, M. Rao, P. Meltzer, D. Schrump (2010)
Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensateOncogene, 29
J. Schiller, D. Harrington, C. Belani, C. Langer, A. Sandler, J. Krook, Junming Zhu, David Johnson (2002)
Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer.The New England journal of medicine, 346 2
H. Hsu, Tsz-Pei Chen, Chein-Hui Hung, Chiaokai Wen, Rou-Kai Lin, Hui‐Chen Lee, Yi-Ching Wang (2007)
Characterization of a multiple epigenetic marker panel for lung cancer detection and risk assessment in plasmaCancer, 110
J. Launay, M. Pino, G. Chironi, J. Callebert, K. Peoc’h, J. Mégnien, J. Mallet, A. Simon, F. Rendu (2009)
Smoking Induces Long-Lasting Effects through a Monoamine-Oxidase Epigenetic RegulationPLoS ONE, 4
(1998)
EpsteinBarr viral DNA in serum of patients with nasopharyngeal carcinoma
S. Leung, B. Zee, B. Ma, E. Hui, F. Mo, M. Lai, K. Chan, L. Chan, W. Kwan, Y. Lo, A. Chan (2006)
Plasma Epstein-Barr viral deoxyribonucleic acid quantitation complements tumor-node-metastasis staging prognostication in nasopharyngeal carcinoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 24 34
P. Anker, H. Mulcahy, Xu Chen, M. Stroun (2004)
Detection of Circulating Tumour DNA in the Blood (Plasma/Serum) of Cancer PatientsCancer and Metastasis Reviews, 18
F. Andriani, D. Conte, Tiziana Mastrangelo, M. Leon, C. Ratcliffe, L. Roz, G. Pelosi, P. Goldstraw, G. Sozzi, U. Pastorino (2004)
Detecting lung cancer in plasma with the use of multiple genetic markersInternational Journal of Cancer, 108
(2004)
Quantification of plasma EpsteinBarr virus DNA in patients with advanced nasopharyngeal carcinoma
O. Gautschi, Colette Bigosch, B. Huegli, M. Jermann, A. Marx, E. Chasse, D. Ratschiller, W. Weder, M. Joerger, D. Betticher, R. Stahel, A. Ziegler (2004)
Circulating deoxyribonucleic Acid as prognostic marker in non-small-cell lung cancer patients undergoing chemotherapy.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 22 20
G. Sozzi, D. Conte, M. Leon, Rosalia Ciricione, L. Roz, C. Ratcliffe, E. Roz, N. Cirenei, M. Bellomi, G. Pelosi, M. Pierotti, U. Pastorino (2003)
Quantification of free circulating DNA as a diagnostic marker in lung cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 21 21
Jin-Ching Lin, Wen-Yi Wang, Kuang Chen, Yau-Huei Wei, W. Liang, J. Jan, R. Jiang (2004)
Quantification of plasma Epstein-Barr virus DNA in patients with advanced nasopharyngeal carcinoma.The New England journal of medicine, 350 24
Y. Lui, K. Chik, R. Chiu, C. Ho, Christopher Lam, Y. Lo (2002)
Predominant hematopoietic origin of cell-free DNA in plasma and serum after sex-mismatched bone marrow transplantation.Clinical chemistry, 48 3
D. Banville, R. Stocco, S. Shen (1995)
Human protein tyrosine phosphatase 1C (PTPN6) gene structure: alternate promoter usage and exon skipping generate multiple transcripts.Genomics, 27 1
H. Usadel, J. Brabender, K. Danenberg, C. Jerónimo, S. Harden, J. Engles, P. Danenberg, Stephen Yang, D. Sidransky (2002)
Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer.Cancer research, 62 2
A. Butt, Ramasamyiyer Swaminathan (2008)
Overview of Circulating Nucleic Acids in Plasma/SerumAnnals of the New York Academy of Sciences, 1137
Michiel Maat, N. Umetani, E. Sunami, R. Turner, D. Hoon (2007)
Assessment of Methylation Events during Colorectal Tumor Progression by Absolute Quantitative Analysis of Methylated AllelesMolecular Cancer Research, 5
S. Leon, B. Shapiro, D. Sklaroff, M. Yaros (1977)
Free DNA in the serum of cancer patients and the effect of therapy.Cancer research, 37 3
J. Tsang, Y. Lo (2007)
Circulating nucleic acids in plasma/serumPathology, 39
K. Ruchusatsawat, J. Wongpiyabovorn, S. Shuangshoti, N. Hirankarn, A. Mutirangura (2006)
SHP-1 promoter 2 methylation in normal epithelial tissues and demethylation in psoriasisJournal of Molecular Medicine, 84
ORIGINAL ARTICLE Epithelial-Specific Methylation Marker A Potential Plasma Biomarker in Advanced Non-small Cell Lung Cancer Chanida Vinayanuwattikun, MD,*† Virote Sriuranpong, MD, PhD,† Suebpong Tanasanvimon, MD,† Poonchavist Chantranuwat, MD,‡ and Apiwat Mutirangura, MD, PhD§ used to develop risk-adaptive treatments for patients with lung Background: Under physiological conditions, leukocytes contrib- cancer. ute the majority of circulating DNA in plasma. Therefore, detection Key Words: SHP-1, Methylation, Biomarker, Lung cancer, Epithe- of methylation at the SHP-1 promoter 2 (SHP1P2) in plasma, which lial-specific methylation marker. represents epithelial tumor-derived circulating nucleic acids, may serve as a potential noninvasive biomarker for non-small cell lung (J Thorac Oncol. 2011;6: 1818–1825) cancer (NSCLC). Materials and Method: A quantitative polymerase chain reaction- based assay was used to determine the level of SHP1P2 methylation ecent studies have indicated that extracellular, freely cir- in plasma. Blood samples were prospectively collected from 58 Rculating nucleic acids in plasma and serum (CNAPS) are patients with advanced NSCLC, 20 patients with early NSCLC, and a valuable biomarker that can be used to detect the presence 52 healthy volunteers. of several diseases, such as cancer, cardiovascular disease, Results: Most of the healthy volunteers exhibited undetectable pulmonary thromboembolism, connective tissue disease, in- levels of SHP1P2
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Nov 1, 2011
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