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EDITORIAL REVIEW Ruby Pawankar Department of Otolaryngology, Nippon Medical School, Tokyo, Japan leukotrienes and prostaglandin. By contrast, the late phase allergic reaction is largely in¯ammatory and occurs Correspondence to Ruby Pawankar, MD, PhD, Department of Otolaryngology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan as a result of the in¯ammatory mediators released by the Fax: +81 3 5685 0830; e-mail: Pawankar_Ruby/ent@nms.ac.jp in®ltrated cells. Mast cells are known to be the central Current Opinion in Allergy and Clinical Immunology 2002, 2:1±5 players in the immediate phase allergic reaction, whereas T cells, basophils and eosinophils are considered crucial 2002 Lippincott Williams & Wilkins for the late phase reaction. However, new knowledge 1528-4050 regarding the pathophysiological mechanisms that un- derlie allergic rhinitis has highlighted the versatile roles of mast cells in allergic in¯ammation [7] and has Introduction emphasized the roles played by structural cells such as It is becoming increasingly evident that the prevalence epithelial cells. of allergic diseases such as allergic rhinoconjunctivitis, atopic asthma and atopic dermatitis is increasing [1±3]. Airway epithelial cells are known to play an integral role Indeed, such diseases range in prevalence from 10 to in airway defence mechanisms via the mucociliary 50% of the general
Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health
Published: Feb 1, 2002
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