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Epithelial cells as immunoregulators in allergic airway diseases

Epithelial cells as immunoregulators in allergic airway diseases EDITORIAL REVIEW Ruby Pawankar Department of Otolaryngology, Nippon Medical School, Tokyo, Japan leukotrienes and prostaglandin. By contrast, the late phase allergic reaction is largely in¯ammatory and occurs Correspondence to Ruby Pawankar, MD, PhD, Department of Otolaryngology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan as a result of the in¯ammatory mediators released by the Fax: +81 3 5685 0830; e-mail: Pawankar_Ruby/ent@nms.ac.jp in®ltrated cells. Mast cells are known to be the central Current Opinion in Allergy and Clinical Immunology 2002, 2:1±5 players in the immediate phase allergic reaction, whereas T cells, basophils and eosinophils are considered crucial 2002 Lippincott Williams & Wilkins for the late phase reaction. However, new knowledge 1528-4050 regarding the pathophysiological mechanisms that un- derlie allergic rhinitis has highlighted the versatile roles of mast cells in allergic in¯ammation [7] and has Introduction emphasized the roles played by structural cells such as It is becoming increasingly evident that the prevalence epithelial cells. of allergic diseases such as allergic rhinoconjunctivitis, atopic asthma and atopic dermatitis is increasing [1±3]. Airway epithelial cells are known to play an integral role Indeed, such diseases range in prevalence from 10 to in airway defence mechanisms via the mucociliary 50% of the general http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Allergy and Clinical Immunology Wolters Kluwer Health

Epithelial cells as immunoregulators in allergic airway diseases

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Copyright
Copyright © 2002 by Lippincott Williams & Wilkins. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise without either the prior written permission of the Publisher or a licence permitting restricted copying issued in the UK by the Copyright Licensing Authority and in the USA by the Copyright Clearance Center. Applications for permission should be addressed to the International Rights Department, Lippincott Williams & Wilkins, 227 East Washington Square, Philadelphia, PA 19106-380, USA, or faxed to (+1) 215 238 4419. 1528-4050/02.
ISSN
1528-4050
eISSN
1473-6322

Abstract

EDITORIAL REVIEW Ruby Pawankar Department of Otolaryngology, Nippon Medical School, Tokyo, Japan leukotrienes and prostaglandin. By contrast, the late phase allergic reaction is largely in¯ammatory and occurs Correspondence to Ruby Pawankar, MD, PhD, Department of Otolaryngology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan as a result of the in¯ammatory mediators released by the Fax: +81 3 5685 0830; e-mail: Pawankar_Ruby/ent@nms.ac.jp in®ltrated cells. Mast cells are known to be the central Current Opinion in Allergy and Clinical Immunology 2002, 2:1±5 players in the immediate phase allergic reaction, whereas T cells, basophils and eosinophils are considered crucial 2002 Lippincott Williams & Wilkins for the late phase reaction. However, new knowledge 1528-4050 regarding the pathophysiological mechanisms that un- derlie allergic rhinitis has highlighted the versatile roles of mast cells in allergic in¯ammation [7] and has Introduction emphasized the roles played by structural cells such as It is becoming increasingly evident that the prevalence epithelial cells. of allergic diseases such as allergic rhinoconjunctivitis, atopic asthma and atopic dermatitis is increasing [1±3]. Airway epithelial cells are known to play an integral role Indeed, such diseases range in prevalence from 10 to in airway defence mechanisms via the mucociliary 50% of the general

Journal

Current Opinion in Allergy and Clinical ImmunologyWolters Kluwer Health

Published: Feb 1, 2002

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