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RESEARCH ARTICLE Epigenetic Modifications of Histone H4 in Lung Neuroendocrine Tumors Faqian Li, MD, PhD,*w Bo Ye, MD, PhD,* Longsheng Hong, MD,w Haodong Xu, MD, PhD,* and Michael C. Fishbein, MDw Pearson correlation. We conclude that progressive loss of Abstract: Global profiling of histone changes in some human H4KA16 and H4KM20 from low to high grade LNETs reflects cancers demonstrated that loss of histone H4 acetylation at the degree of differentiation and proliferative activity. These lysine16 (H4KA16) and trimethylation at lysine 20 (H4KM20) histone modifications may serve as tumor biomarkers that may was a common hallmark of cancer. It is not clear whether these aid in diagnosis and prediction of clinical outcome. epigenetic changes also exist in neuroendocrine carcinomas. We Key Words: lung, neuroendocrine tumors, typical carcinoid, semiquantitatively analyzed 32 cases of lung neuroendocrine atypical carcinoid, large cell neuroendocrine carcinoma, small tumors (LNETs) immunohistochemically stained with H4KA16, cell lung carcinoma, histone, epigenetic H4KM20, and Ki67 antibodies by calculating cumulative scores based on the sum of the product of nuclear stain intensity (1-3) (Appl Immunohistochem Mol Morphol 2011;19:389–394) and percentages of positive cells in each category. H4KA16 and H4KM20 levels were compared among typical carcinoid (TC, 11), atypical carcinoid (AC,
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Oct 1, 2011
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