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MALIGNANCIES OF THE THYMUS Eric A. Engels, MD, MPH* conditions that often accompany thymoma, such as myasthenia Background: Thymoma is a rare malignancy of unknown etiology. gravis, blood disorders, and connective tissue diseases. Methods: The author examined patterns in thymoma incidence in The cause of thymoma is unknown. Because of the the US general population using data from Surveillance, Epidemi- rarity of this cancer, most studies of thymoma have been ology, and End Results (SEER) cancer registries. Prior studies based on small numbers of clinical cases recruited at single concerning the risk of additional malignancies in thymoma patients treatment centers. In this article, the author reviews the were reviewed. epidemiology of this malignancy using data collected by Results: Based on cancer registry data, the overall incidence of thy- population-based cancer registries to outline some possible moma in the US is 0.13 per 100,000 person-years. Thymoma is clues to its etiology. The author also reviews studies that exceedingly uncommon in children and young adults, rises in incidence have examined the associations between thymoma and in middle age, and peaks in the seventh decade of life. Thymoma other malignancies, because such studies can shed light on incidence is especially high among
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Oct 1, 2010
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