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Enhancement Characteristics of Ultrasmall Superparamagnetic Iron Oxide Particle Within the Prostate Gland in Patients With Primary Prostate Cancer

Enhancement Characteristics of Ultrasmall Superparamagnetic Iron Oxide Particle Within the... ORIGINAL ARTICLE Enhancement Characteristics of Ultrasmall Superparamagnetic Iron Oxide Particle Within the Prostate Gland in Patients With Primary Prostate Cancer Chao-Shiang Li, MD,*Þ Mukesh G. Harisinghani, MD,* Wen-Chiung Lin, MD,*þ Martha Braschi, MD,* Peter F. Hahn, MD, PhD,* and Peter R. Mueller, MD* cancer, it is still difficult to create a standardized vendor- Objective: To analyze the enhancement of the prostate using 5 independent protocol. ultrasmall superparamagnetic iron oxide (USPIO)Yenhanced mag- In recent years, ultrasmall superparamagnetic iron netic resonance imaging in patients with prostate cancer. oxide (USPIO)Yenhanced MRI showed improved accuracy Methods: Sixty patients were enrolled. The signal-to-noise ratios to differentiate benign from malignant lymph nodes in (SNRs) of the central and peripheral zones (CZ and PZ, respectively) patients with prostate cancer and various other primary of the prostate were evaluated on T2- and T2*-weighted magnetic 6Y10 tumors. In addition, the accumulation of USPIO nano- resonance imaging before and 24 hours after USPIO-enhanced MRI. particles in tumors with subsequent change in MR signals has The changes in SNR after USPIO-enhanced MRI were analyzed and been investigated in a few experimental and clinical correlated with serum prostate-specific antigen and histopathologic 11Y17 studies. The purpose of our study was to analyze http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Computer Assisted Tomography Wolters Kluwer Health

Enhancement Characteristics of Ultrasmall Superparamagnetic Iron Oxide Particle Within the Prostate Gland in Patients With Primary Prostate Cancer

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ISSN
0363-8715
eISSN
1532-3145
DOI
10.1097/RCT.0b013e318136e194
pmid
18664836
Publisher site
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Abstract

ORIGINAL ARTICLE Enhancement Characteristics of Ultrasmall Superparamagnetic Iron Oxide Particle Within the Prostate Gland in Patients With Primary Prostate Cancer Chao-Shiang Li, MD,*Þ Mukesh G. Harisinghani, MD,* Wen-Chiung Lin, MD,*þ Martha Braschi, MD,* Peter F. Hahn, MD, PhD,* and Peter R. Mueller, MD* cancer, it is still difficult to create a standardized vendor- Objective: To analyze the enhancement of the prostate using 5 independent protocol. ultrasmall superparamagnetic iron oxide (USPIO)Yenhanced mag- In recent years, ultrasmall superparamagnetic iron netic resonance imaging in patients with prostate cancer. oxide (USPIO)Yenhanced MRI showed improved accuracy Methods: Sixty patients were enrolled. The signal-to-noise ratios to differentiate benign from malignant lymph nodes in (SNRs) of the central and peripheral zones (CZ and PZ, respectively) patients with prostate cancer and various other primary of the prostate were evaluated on T2- and T2*-weighted magnetic 6Y10 tumors. In addition, the accumulation of USPIO nano- resonance imaging before and 24 hours after USPIO-enhanced MRI. particles in tumors with subsequent change in MR signals has The changes in SNR after USPIO-enhanced MRI were analyzed and been investigated in a few experimental and clinical correlated with serum prostate-specific antigen and histopathologic 11Y17 studies. The purpose of our study was to analyze

Journal

Journal of Computer Assisted Tomography – Wolters Kluwer Health

Published: Jul 1, 2008

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