Effects of Two Forms of Hypertension on Atherosclerosis in the Hyperlipidemic Baboon
Effects of Two Forms of Hypertension on Atherosclerosis in the Hyperlipidemic Baboon
McGill, Henry C.; Carey, Kenneth D.; McMahan, C. Alex; Marinez, Yolan N.; Cooper, Thomas E.; Mott, Glen E.; Schwartz, Colin J.
1985-09-01 00:00:00
We examined the relationship of hypertension and plasma renin activity to atherogenesis in 48 moderately hyperlipidemic (total serum cholesterol was about 200 mg/dl) baboons (Papiosp.). We used renal artery stenosis (two-kidney, one clip model) to produce hypertension associated with elevated plasma renin activity, and used cellophane wrapping of both kidneys (bilateral perinephritis model) to produce hypertension with normal renin activity. Renal artery stenosis and bilateral perinephritis increased both systolic and diastolic blood pressure by about 30 mm Hg. Renal artery stenosis approximately doubled, but bilateral perinephritis did not change plasma renin activity.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngArteriosclerosisWolters Kluwer Healthhttp://www.deepdyve.com/lp/wolters-kluwer-health/effects-of-two-forms-of-hypertension-on-atherosclerosis-in-the-ubKyRTq8Ab
Effects of Two Forms of Hypertension on Atherosclerosis in the Hyperlipidemic Baboon
We examined the relationship of hypertension and plasma renin activity to atherogenesis in 48 moderately hyperlipidemic (total serum cholesterol was about 200 mg/dl) baboons (Papiosp.). We used renal artery stenosis (two-kidney, one clip model) to produce hypertension associated with elevated plasma renin activity, and used cellophane wrapping of both kidneys (bilateral perinephritis model) to produce hypertension with normal renin activity. Renal artery stenosis and bilateral perinephritis increased both systolic and diastolic blood pressure by about 30 mm Hg. Renal artery stenosis approximately doubled, but bilateral perinephritis did not change plasma renin activity.
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