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Transport of125l-albumin by isolated segments of canine common carotid arteries was studied in vitro at zero transmural pressure. Sinusoidal oscillatory variations in length (peak change 4%) for 15 minutes at frequencies of 5 and 10 Hz caused 40% increase in 125l-albumin uptake, and also a 30% increase in the apparent luminal surface area. Changes in the duration and frequency of oscillation indicate that the total number of oscillations (= frequency X duration) was the critical parameter in causing these effects. The increase in apparent luminal surface area was correlated with regional flattening of the internal elastic lamina and the overlying endotheiial cells, as demonstrated by transmission and scanning electron microscopy. Endotheiial vesicles were counted with the aid of ruthenium red as a postfixation extracellular marker. The ratio of unstained free vesicles to total vesicles averaged0.083 in the control state and decreased slightly to 0.070 after oscillation. Although the decrease in free vesicle population indicated an acceleration of vesicle diffusion, our theoretical computations showed that the resulting increase in vesicle flux was negligible. The increase in 125l-albumin uptake by the artery following mechanical oscillation is mainly attributable to the increase in apparent luminal surface area.
Arteriosclerosis – Wolters Kluwer Health
Published: Sep 1, 1981
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