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- Copyright
- © 1990 by American Heart Association, Inc.
- ISSN
- 0276-5047
Abstract
To elucidate the mechanism of cholesterol accumulation In cells under hypoxlc conditions, we tested the effects of hypoxia on sterol synthesis, on the activity of acyl-CoA: cholesterol acyltransferase (ACAT), and on the efflux of cholesterol In cultured rabbit skin fibroblasts. Sterol synthesis was measured by the Incorporation of14C-acetate Into sterol, and ACAT activity, by the Incorporation of 14C-oleate Into cholesteryl ester. Hypoxia suppressed both sterol synthesis and the efflux of cholesterol but Increased ACAT activity. These results suggest that hypoxia disturbs the balance of cholesterol metabolism in cells and Induces Intracellular llpld accumulation.
Journal
Arteriosclerosis – Wolters Kluwer Health
Published: Jan 1, 1990