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Editorial overview cell dysfunction and exhaustion in HIV infection

Editorial overview cell dysfunction and exhaustion in HIV infection EDITORIAL URRENT Editorial overview: cell dysfunction and exhaustion PINION in HIV infection a,b,c d,e Nabila Seddiki and Daniel E. Kaufmann Since the initial descriptions of CD4 T cell depletion chronic infection has been well demonstrated over as a critical factor associated with progression to recent years. Kuchroo et al. (pp. 439–445) review AIDS, our understanding of immune dysfunction recent findings on their role in CD8 T cell exhaus- in HIV infection has dramatically evolved. Over the tion and discuss their interplay. However, recent past decade, in particular, technical progress and data show that CD4 T cell dysfunction is not conceptual advances have allowed the exploration a copycat of T cell impairment and is, in part, of a wide array of qualitative and functional changes governed by distinct mechanisms. Morou et al. that occur in multiple cell types and several com- (pp. 446–451) underline the importance of CD4 partments of the body. The realization that chronic T cell plasticity in infectious diseases and the con- immune activation is a major driving force in dis- tributing roles of both skewing of CD4 T cell differ- ease progression and associated with clinical com- entiation and exhaustion mechanisms. Seddiki and plications even in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Editorial overview cell dysfunction and exhaustion in HIV infection

Kaufmann, Daniel E.
Current Opinion in HIV and Aids , Volume 9 (5) – Sep 1, 2014
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Copyright
© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins
ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0000000000000098
pmid
25023624
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL URRENT Editorial overview: cell dysfunction and exhaustion PINION in HIV infection a,b,c d,e Nabila Seddiki and Daniel E. Kaufmann Since the initial descriptions of CD4 T cell depletion chronic infection has been well demonstrated over as a critical factor associated with progression to recent years. Kuchroo et al. (pp. 439–445) review AIDS, our understanding of immune dysfunction recent findings on their role in CD8 T cell exhaus- in HIV infection has dramatically evolved. Over the tion and discuss their interplay. However, recent past decade, in particular, technical progress and data show that CD4 T cell dysfunction is not conceptual advances have allowed the exploration a copycat of T cell impairment and is, in part, of a wide array of qualitative and functional changes governed by distinct mechanisms. Morou et al. that occur in multiple cell types and several com- (pp. 446–451) underline the importance of CD4 partments of the body. The realization that chronic T cell plasticity in infectious diseases and the con- immune activation is a major driving force in dis- tributing roles of both skewing of CD4 T cell differ- ease progression and associated with clinical com- entiation and exhaustion mechanisms. Seddiki and plications even in

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: Sep 1, 2014

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