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EDITORIAL URRENT Distinct roles for dietary protein and amino acids PINION in health and disease a b,c,d Rene´ Koopman and Rajavel Elango Dietary protein and amino acids are of vital impor- severe multisystemic diseases affecting brain, liver tance for growth and to maintain tissue size and and other organs (Koz ˇich et al., pp. 55–61). Although homeostasis throughout all life-stages. Amino acids novel enzyme replacement therapies are being should not only be seen as building blocks of protein developed, dietary amino acid management as some of the amino acids have distinct signaling remains a primary treatment modality, and stable roles and metabolic properties [1]. Although amino isotope based methods are well suited to explore diet acids are classically divided into indispensable (i.e. therapies in in-born errors [4]. need to be consumed through foods) and dispens- Disease states have a profound effect on protein able or conditional indispensable amino acids, this metabolism in skeletal muscle, changing the bal- classification does not differentiate amino acids on ance between protein synthesis and degradation, their important functions. For example, recent work leading to a loss in muscle. In some conditions this has highlighted the important role of amino acids imbalance is relatively small
Current Opinion in Clinical Nutrition & Metabolic Care – Wolters Kluwer Health
Published: Jan 6, 2021
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