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Circulation: Cardiovascular Imaging EDITORIAL Dysfunctional Postprandial Flow Changes, Adverse Cardiac Remodeling, and Hypertension Follow Your Heart but Trust Your Gut? See Article by Hauser et al Ricardo Ladeiras-Lopes, MD Chiara Bucciarelli-Ducci, besity is a major public health problem in the pediatric population in the MD, PhD United States, with ≈1 of 5 individuals aged 2 to 19 years being obese. OEven at this early stage of life, obesity negatively impacts cardiovascular health, being associated with myocardial impairment, endothelial dysfunction, and systemic hypertension, as well as increased inflammation and impaired glucose metabolism. The autonomic nervous system—a modulatory hub of cardiovascular function and metabolic homeostasis—is also deranged in obese children, and, therefore, its dysfunction might provide an integrative understanding of the full pathophysiological cascade. In the current issue, Hauser et al describe that overweight/obese adolescents are more likely to have a dysfunctional splanchnic vascular response to high-calorie food ingestion (mediated by sympathetic nervous system), which was associated with higher prevalence of concentric left ventricular hypertrophy (LVH) and hyper- tension (take-home Figure). The normal splanchnic vascular response to the inges- tion of high-calorie food is mediated by the sympathetic nervous system and is associated with vasodilatation and increased blood flow. In the
Circulation: Cardiovascular Imaging – Wolters Kluwer Health
Published: Nov 1, 2019
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