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Drugs can induce cardiac failure by several mechanisms: fluid overload is usually due to intravenous infusion but can also occur after gut or bladder irrigation, and as a result of fluid and water retention; systemic hypertension is a complication of treatment with cyclosporin and other drugs; drugs can also cause cardiac dysfunction through negative inotropic effects, arrhythmia, or heart muscle damage. Cancer chemotherapy agents, particularly anthracyclines, are the most important causes of this last adverse effect.
Adverse Drug Reaction Bulletin – Wolters Kluwer Health
Published: Aug 1, 1997
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