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a b Elizabeth Phillips and Simon Mallal Purpose of review Introduction Drug hypersensitivity has been reported to occur 100 times From the inception of HIV disease it became clear that more commonly in those living with HIV. In the first decade the immune dysregulation associated with HIV has some of HIV treatment, this mainly involved drugs used to treat important clinical consequences, including a higher inci- HIV-related infections but now primarily includes drugs dence of cutaneous disease as well as drug-associated used to treat HIV. This review focuses on the current hypersensitivity reactions [1]. Initially this was illustrated knowledge of the epidemiology, pathophysiology and with drugs used to treat infections and other complications clinical features of drug hypersensitivity reactions of drugs associated with HIV such as dapsone, sulfamethoxazole and used in the management of the HIV-infected patient. antituberculous therapy. With the evolution of more Recent findings potent combination antiretroviral regimens as well as Our understanding of the immunogenetics and host an increasing number of new antiretroviral agents, many predisposition to drug hypersensitivity has been advanced of the complications associated with HIV have become considerably by the antiretroviral drugs abacavir and much less common and in the developed world at
Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health
Published: Aug 1, 2007
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