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Does Lung Adenocarcinoma Subtype Predict Patient Survival? A Clinicopathologic Study Based on the New International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Lung Adenocarcinoma Classification

Does Lung Adenocarcinoma Subtype Predict Patient Survival? A Clinicopathologic Study Based on the... ORIGINAL ARTICLE Does Lung Adenocarcinoma Subtype Predict Patient Survival? A Clinicopathologic Study Based on the New International Association for the Study of Lung Cancer/American Thoracic Society/ European Respiratory Society International Multidisciplinary Lung Adenocarcinoma Classification Prudence A. Russell, MBBS, FRCPA,* Zoe Wainer, BMBS,†‡ Gavin M. Wright, MBBS, FRACS,†‡§ Marissa Daniels, MBBS,§ Matthew Conron, MBBS, FRACP, and Richard A. Williams, MBBS, FRCPA, PhD* Results: We confirmed that the new subtypes of adenocarcinoma in Introduction: Lung adenocarcinoma is a heterogeneous group of situ, minimally invasive adenocarcinoma and lepidic-predominant tumors with a highly variable prognosis, not well predicted by the adenocarcinoma had a 5-year survival approaching 100%, whereas current pathologic classification system. The 2004 World Health micropapillary-predominant and solid with mucin-predominant adeno- Organization classification results in virtually all tumors encoun- carcinomas were associated with particularly poor survival. Papillary- tered in clinical practice being allocated to the adenocarcinoma of predominant and acinar-predominant adenocarcinomas had an interme- mixed subtype category. A new classification developed by an diate prognosis. This effect persisted after controlling for stage. international multidisciplinary expert panel sponsored by the Inter- Conclusions: Classification of lung adenocarcinoma according to national Association for the Study of Lung Cancer, American the new International Association for the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Does Lung Adenocarcinoma Subtype Predict Patient Survival? A Clinicopathologic Study Based on the New International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Lung Adenocarcinoma Classification

Journal of Thoracic Oncology , Volume 6 (9) – Sep 1, 2011

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ISSN
1556-0864
DOI
10.1097/JTO.0b013e318221f701
pmid
21642859
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Does Lung Adenocarcinoma Subtype Predict Patient Survival? A Clinicopathologic Study Based on the New International Association for the Study of Lung Cancer/American Thoracic Society/ European Respiratory Society International Multidisciplinary Lung Adenocarcinoma Classification Prudence A. Russell, MBBS, FRCPA,* Zoe Wainer, BMBS,†‡ Gavin M. Wright, MBBS, FRACS,†‡§ Marissa Daniels, MBBS,§ Matthew Conron, MBBS, FRACP, and Richard A. Williams, MBBS, FRCPA, PhD* Results: We confirmed that the new subtypes of adenocarcinoma in Introduction: Lung adenocarcinoma is a heterogeneous group of situ, minimally invasive adenocarcinoma and lepidic-predominant tumors with a highly variable prognosis, not well predicted by the adenocarcinoma had a 5-year survival approaching 100%, whereas current pathologic classification system. The 2004 World Health micropapillary-predominant and solid with mucin-predominant adeno- Organization classification results in virtually all tumors encoun- carcinomas were associated with particularly poor survival. Papillary- tered in clinical practice being allocated to the adenocarcinoma of predominant and acinar-predominant adenocarcinomas had an interme- mixed subtype category. A new classification developed by an diate prognosis. This effect persisted after controlling for stage. international multidisciplinary expert panel sponsored by the Inter- Conclusions: Classification of lung adenocarcinoma according to national Association for the Study of Lung Cancer, American the new International Association for the

Journal

Journal of Thoracic OncologyWolters Kluwer Health

Published: Sep 1, 2011

References