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Distribution of Basal/Myoepithelial Markers in Benign and Malignant Bronchioloalveolar Proliferations of the Lung

Distribution of Basal/Myoepithelial Markers in Benign and Malignant Bronchioloalveolar... Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Distribution of Basal/Myoepithelial Markers in Benign and Malignant Bronchioloalveolar Proliferations of the Lung Reda S. Saad, MD, PhD, Yulin L. Liu, MD, PhD, and Jan F. Silverman, MD screening, there is a rise in the number of small-sized lung 3–5 Abstract: We investigated the staining pattern of commonly used cancers identified at early stage. Most of these lung basal cell/myoepithelial markers, such as p63 (a p53-homo- cancers, representing a heterogeneous group of adeno- logous nuclear protein), basal cell-specific cytokeratin antibody carcinomas ranging from minimal to overtly invasive (34bE12, K903), and smooth muscle myosin heavy chain cancer, have different prognosis. Therefore, it is crucial (SMMHC) in benign and malignant bronchioloalveolar pro- to subclassify this heterogeneous group to better define liferations of the lung. We studied 85 lung lesions consisting of their biologic behavior. 35 bronchioloalveolar carcinoma, 30 well-differentiated adeno- Bronchioloalveolar carcinoma is relatively uncom- carcinoma, and 20 cases of benign lung lesions. In normal lung, mon type of pulmonary adenocarcinoma. The World p63, K903, and SMMHC decorated the basal cells of large and Health Organization redefined bronchioloalveolar carci- small airways and occasional cells of terminal bronchioles. In noma to include only http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Distribution of Basal/Myoepithelial Markers in Benign and Malignant Bronchioloalveolar Proliferations of the Lung

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Publisher
Wolters Kluwer Health
ISSN
1541-2016
DOI
10.1097/PAI.0b013e3181c6feec
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Abstract

Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Distribution of Basal/Myoepithelial Markers in Benign and Malignant Bronchioloalveolar Proliferations of the Lung Reda S. Saad, MD, PhD, Yulin L. Liu, MD, PhD, and Jan F. Silverman, MD screening, there is a rise in the number of small-sized lung 3–5 Abstract: We investigated the staining pattern of commonly used cancers identified at early stage. Most of these lung basal cell/myoepithelial markers, such as p63 (a p53-homo- cancers, representing a heterogeneous group of adeno- logous nuclear protein), basal cell-specific cytokeratin antibody carcinomas ranging from minimal to overtly invasive (34bE12, K903), and smooth muscle myosin heavy chain cancer, have different prognosis. Therefore, it is crucial (SMMHC) in benign and malignant bronchioloalveolar pro- to subclassify this heterogeneous group to better define liferations of the lung. We studied 85 lung lesions consisting of their biologic behavior. 35 bronchioloalveolar carcinoma, 30 well-differentiated adeno- Bronchioloalveolar carcinoma is relatively uncom- carcinoma, and 20 cases of benign lung lesions. In normal lung, mon type of pulmonary adenocarcinoma. The World p63, K903, and SMMHC decorated the basal cells of large and Health Organization redefined bronchioloalveolar carci- small airways and occasional cells of terminal bronchioles. In noma to include only

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: May 1, 2010

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