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Downloaded from http://journals.lww.com/appliedimmunohist by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/10/2020 RESEARCH ARTICLE Distinguishing Clear Cell Renal Cell Carcinoma, Retroperitoneal Paraganglioma, and Adrenal Cortical Lesions on Limited Biopsy Material Utility of Immunohistochemical Markers James E. Lapinski, MD, Longwen Chen, MD, PhD, and Ming Zhou, MD, PhD enal cell carcinoma (RCC) accounts for 2% to 4% Abstract: Retroperitoneal recurrence of clear cell renal cell Rof all adult malignancies, but more than 90% of carcinoma (CCRCC) after surgical resection is often investi- malignancies involving the kidney in both males and gated by needle biopsy and frequently requires immunohisto- females. The most common histologic subtype of RCC is chemistry to distinguish from other lesions with similar clear cell RCC (CCRCC), accounting for 60% to 80% histology. This study explores the diagnostic utility of a panel of RCC cases. CCRCC is well known for its tendency to of immunohistochemical markers and emphasizes potential metastasize. Up to one-third of patients with localized pitfalls in dealing with this differential diagnosis. A tissue CCRCC will eventually develop local and distant recur- microarray with 1 mm tissue cores was constructed to include rence after surgical resection, after 10 years or more in 21 CCRCC, 19 adrenocortical lesions, and 15 retroperitoneal some
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Oct 1, 2010
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