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CASE REPORT Diffuse Large B-cell Lymphoma With Aberrant Expression of the T-cell Antigens CD2 and CD7 Nikhil A. Sangle, MD, FRCPath,*w Archana M. Agarwal, MD,*w Kristi J. Smock, MD,*w Matthew O. Leavitt, MD,z Roger Warnke, MD,y David Bahler, MD, PhD,*w and Sherrie L. Perkins, MD, PhD*w tion of immunoglobulin surface light chain restriction by Abstract: Diffuse large B-cell lymphoma is the most common flow cytometry in the majority of cases. The presence of type of non-Hodgkin lymphoma. Although, aberrant expression positive PAX-5 immunostaining, in particular, is strongly of a single T-cell-associated antigen (exclusive of CD5) on associated with B-cell differentiation as PAX-5 is a B-cell- diffuse large B-cell lymphoma has occasionally been described restricted transcription factor. Aberrant expression of in the literature, cases that show coexpression of Z2 T-cell T-cell-associated antigens (exclusive of CD5) on DLBCL 5–7 antigens on a well-documented case of diffuse large B-cell has been described in the literature. Coexpression of lymphoma are extremely rare. Here, we describe a well- Z2 T-cell-associated antigens (exclusive of CD5) on characterized case of diffuse large B-cell lymphoma that showed clonal B-cells, is however rare, and has been described by aberrant coexpression of 2 T-cell-associated antigens, CD2 and only a
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Dec 1, 2011
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