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RESEARCH ARTICLE Differentiating Small Cell Carcinoma From Squamous Cell Carcinoma in Cytologic Specimens: A Head-to-Head Comparison of p40 and p63 Using Cell Block Immunocytochemistry Michael P. Gailey, DO, Andrew M. Bellizzi, MD, and Chris S. Jensen, MD ficult for conventional bronchoscopy, EBUS-guided and Abstract: Distinguishing small cell carcinoma (SCC) from poorly EUS-guided FNAs are frequently performed on high- differentiated squamous cell carcinoma (SCCA) can be challeng- stage, nonsurgical patients with the intent of securing a ing on fine needle aspiration (FNA). p63 immunocytochemistry is cancer diagnosis and, through tumor subtyping and mo- frequently used to support the presence of squamous differ- lecular testing, evaluating whether targeted agents may be entiation. However, issues relating to specificity have arisen, and applicable. Diagnostic material in these instances be- the common pan-p63 clone (4A4) has been challenged by anti- comes a highly valuable, scarce resource, and it is critical bodies specific for the DN isoform of p63 (p40), which show 1 that the specimen be used judiciously. superior specificity for SCCA. A total of 50 SCC and 25 SCCA As such, increasing effort has been invested to identify FNA cell blocks were stained with antibodies for p40, p63, K903, the most useful panels
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Apr 1, 2015
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