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Diagnostic Utility of STAT6 Immunohistochemistry in the Diagnosis of Fat-forming Solitary Fibrous Tumors

Diagnostic Utility of STAT6 Immunohistochemistry in the Diagnosis of Fat-forming Solitary Fibrous... LETTER TO THE EDITOR slowly growing, fibroblastic neoplasm, hibit at least focal hypercellularity, Diagnostic Utility of characterized by the histologic features of showing increased mitotic index (>4 typical or cellular SFT with, in addition, mitoses per 10 HPF), variable cytologic STAT6 a variably prominent mature adipocytic atypia, and/or necrosis. Nuclear signal 1–3 Immunohistochemistry component. The fat-forming variant transducer and activator of transcription of SFT occurs predominantly in the ret- 6 (STAT6) immunoreactivity has been in the Diagnosis of roperitoneum and in the deep soft tissues reported as an excellent surrogate marker of the lower extremities and the trunk. for the NAB2-STAT6 gene fusion, which Fat-forming Solitary Although fat-forming SFTs are generally is the defining driver mutation of benign Fibrous Tumors regarded as nonrecurring and non- and malignant SFTs. Recent studies de- metastasizing benign tumors, they can scribed the utility of STAT6 expression To the Editor: show malignant behavior and a few fat- as a tool to distinguish SFT from a large Fat-forming solitary fibrous tumor forming SFTs with malignant histologic group of benign and malignant 4,5 6–8 (SFT) (also known as lipomatous he- features have been reported. Histolog- histologic mimics. In these studies mangiopericytoma) is a rare, usually ically, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Diagnostic Utility of STAT6 Immunohistochemistry in the Diagnosis of Fat-forming Solitary Fibrous Tumors

Applied Immunohistochemistry & Molecular Morphology , Volume Publish Ahead of Print – Dec 1, 2014

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Copyright
Copyright © 2014 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0000000000000166
pmid
25517867
Publisher site
See Article on Publisher Site

Abstract

LETTER TO THE EDITOR slowly growing, fibroblastic neoplasm, hibit at least focal hypercellularity, Diagnostic Utility of characterized by the histologic features of showing increased mitotic index (>4 typical or cellular SFT with, in addition, mitoses per 10 HPF), variable cytologic STAT6 a variably prominent mature adipocytic atypia, and/or necrosis. Nuclear signal 1–3 Immunohistochemistry component. The fat-forming variant transducer and activator of transcription of SFT occurs predominantly in the ret- 6 (STAT6) immunoreactivity has been in the Diagnosis of roperitoneum and in the deep soft tissues reported as an excellent surrogate marker of the lower extremities and the trunk. for the NAB2-STAT6 gene fusion, which Fat-forming Solitary Although fat-forming SFTs are generally is the defining driver mutation of benign Fibrous Tumors regarded as nonrecurring and non- and malignant SFTs. Recent studies de- metastasizing benign tumors, they can scribed the utility of STAT6 expression To the Editor: show malignant behavior and a few fat- as a tool to distinguish SFT from a large Fat-forming solitary fibrous tumor forming SFTs with malignant histologic group of benign and malignant 4,5 6–8 (SFT) (also known as lipomatous he- features have been reported. Histolog- histologic mimics. In these studies mangiopericytoma) is a rare, usually ically,

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Dec 1, 2014

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