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- Copyright
- Copyright © 2005 by Lippincott Williams & Wilkins
- ISSN
- 1541-2016
- DOI
- 10.1097/01.pai.0000132190.39351.9b
- Publisher site
- See Article on Publisher Site
Abstract
RESEARCH Diagnostic Utility of Cell Cycle and Apoptosis Regulatory Proteins in Verrucous Squamous Carcinoma Patrick A. Adegboyega, MD,* Nahal Boromound, MD,* and Daniel H. Freeman, PhD† may be helpful in resolving diagnostic problems associated with ver- Abstract: A major problem in the diagnosis of verrucous squamous rucous carcinoma. cell carcinoma is the lack of readily reproducible objective criteria for Key Words: apoptosis, squamous cell carcinoma, verrucous caraci- distinguishing this malignant lesion from reactive epithelial hyperpla- noma, acanthosis, p16, p21, p53, Ki67 sia. Both lesions are characterized by thickened (well-differentiated) squamous epithelium without cellular atypia and subjacent stroma (Appl Immunohistochem Mol Morphol 2005;13:171–177) densely infiltrated by lymphocytes and plasma cells. This study was carried out to evaluate the use of cell cycle and apoptosis-related regu- errucous carcinoma was first described by Ackerman in latory proteins in the diagnosis of verrucous carcinoma. The study V1948 as a variant of squamous cell carcinoma of the oral materials consisted of representative formalin-fixed and paraffin- embedded tissue blocks from 19 cases of verrucous carcinoma, 18 cavity. Since then, it has also been described at other sites in classic squamous cell carcinoma, and 14 squamous epithelial hyper- the head and neck and upper aerodigestive regions,
Journal
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Jun 1, 2005