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RESEARCH ARTICLE Diagnostic and Prognostic Role of HBME-1, Galectin-3, and b-Catenin in Poorly Differentiated and Anaplastic Thyroid Carcinomas Esther D. Rossi, MD, PhD,* Patrizia Straccia, BD,* Marianna Palumbo, MD,* Egidio Stigliano, BD,* Luca Revelli, MD,w Celestino P. Lombardi, MD,w Giuseppe Santeusanio, MD,z Alfredo Pontecorvi, MD, PhD,y and Guido Fadda, MD, MIAC* Key Words: poorly differentiated thyroid carcinoma, anaplastic Aim: Thyroid cancer represents the first endocrine malignant thyroid carcinoma, immunohistochemistry, prognosis neoplasm, accounting for 1% of human malignancy. The ma- (Appl Immunohistochem Mol Morphol 2013;21:237–241) jority of which are well-differentiated cancer representing up to 90% of thyroid cancer and pursuing a favorable clinical course. The groups of poorly differentiated thyroid cancer (PDC) and hyroid cancer represents the most frequent malignant anaplastic thyroid cancer (ATC) have a poor outcome and need Tendocrine neoplasm accounting for 1% of all human a strict clinical surveillance. carcinomas with an incidence of up to 60 cases per million Materials and Methods: Thirty-four cases including 23 PDC/ people a year, which ranks this tumor among the 5 most insular cancer and 9 ATC were examined for the expression of important malignant neoplasms in patients between 15 an immunohistochemical panel made up by HBME-1, galectin- and 45
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: May 1, 2013
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