Access the full text.
Sign up today, get DeepDyve free for 14 days.
B. Halpert, M. Young (1948)
Carcinosarcoma of the mammary gland.Surgery, 23 2
M. Carter, J. Hornick, S. Lester, C. Fletcher (2006)
Spindle Cell (Sarcomatoid) Carcinoma of the Breast: A Clinicopathologic and Immunohistochemical Analysis of 29 CasesThe American Journal of Surgical Pathology, 30
B. Weigelt, B. Kreike, J. Reis-Filho (2009)
Metaplastic breast carcinomas are basal-like breast cancers: a genomic profiling analysisBreast Cancer Research and Treatment, 117
A. Nassar, N. Sookhan, M. Santisteban, S. Bryant, J. Boughey, T. Giorgadze, A. Degnim (2010)
Diagnostic utility of snail in metaplastic breast carcinomaDiagnostic Pathology, 5
C. Pezzi, L. Patel-Parekh, Karin Cole, J. Franko, V. Klimberg, K. Bland (2006)
Characteristics and Treatment of Metaplastic Breast Cancer: Analysis of 892 Cases from the National Cancer Data BaseAnnals of Surgical Oncology, 14
C. Adem, C. Reynolds, H. Adlakha, P. Roche, A. Nascimento (2002)
Wide spectrum screening keratin as a marker of metaplastic spindle cell carcinoma of the breast: an immunohistochemical study of 24 patientsHistopathology, 40
(1984)
: their prognoses
H. Gallager (1984)
Pathologic types of breast cancer: Their prognosesCancer, 53
B. Hennessy, A. González-Angulo, K. Stemke‐Hale, M. Gilcrease, S. Krishnamurthy, Ju-Seog Lee, J. Fridlyand, A. Sahin, R. Agarwal, C. Joy, Wenbin Liu, D. Stivers, K. Baggerly, M. Carey, A. Lluch, C. Monteagudo, Xiaping He, V. Weigman, C. Fan, J. Palazzo, G. Hortobagyi, L. Nolden, Nicholas Wang, V. Valero, J. Gray, C. Perou, G. Mills (2009)
Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics.Cancer research, 69 10
B. Dunne, Andrew Lee, S. Pinder, J. Bell, I. Ellis (2003)
An immunohistochemical study of metaplastic spindle cell carcinoma, phyllodes tumor and fibromatosis of the breast.Human pathology, 34 10
H. Gobbi, J. Simpson, Alexander Borowsky, Roy Jensen, D. Page (1999)
Metaplastic breast tumors with a dominant fibromatosis‐like phenotype have a high risk of local recurrenceCancer, 85
Eric Wargotz, P. Deos, H. Norris (1989)
Metaplastic carcinomas of the breast. II. Spindle cell carcinoma.Human pathology, 20 8
Pathologic types of breast
W. Davis, B. Hennessy, G. Babiera, K. Hunt, V. Valero, T. Buchholz, N. Sneige, M. Gilcrease (2005)
Metaplastic Sarcomatoid Carcinoma of the Breast With Absent or Minimal Overt Invasive Carcinomatous Component: A MisnomerThe American Journal of Surgical Pathology, 29
D. El-Rehim, S. Pinder, C. Paish, J. Bell, R. Blamey, J. Robertson, R. Nicholson, I. Ellis (2004)
Expression of luminal and basal cytokeratins in human breast carcinomaThe Journal of Pathology, 203
A. Bahrami, Allen Gown, Geoffrey Baird, M. Hicks, A. Folpe (2008)
Aberrant expression of epithelial and neuroendocrine markers in alveolar rhabdomyosarcoma: a potentially serious diagnostic pitfallModern Pathology, 21
H. Wada, T. Enomoto, M. Tsujimoto, T. Nomura, Y. Murata, K. Shroyer (1998)
Carcinosarcoma of the breast: molecular-biological study for analysis of histogenesis.Human pathology, 29 11
M. Teixeira, H. Qvist, P. Bøhler, N. Pandis, S. Heim (1998)
Cytogenetic analysis shows that carcinosarcomas of the breast are of monoclonal originGenes, 22
Xiaojuan Wang, I. Mori, Wei-hua Tang, Qifeng Yang, Misa Nakamura, Yasushi Nakamura, Misako Sato, T. Sakurai, Kakudo Kennichi (2001)
Metaplastic Carcinoma of the Breast: p53 Analysis Identified the Same Point Mutation in the Three Histologic ComponentsModern Pathology, 14
T. Chao, Chia‐Siu Wang, Shin-Cheh Chen, Miin‐Fu Chen (1999)
Metaplastic carcinomas of the breastJournal of Surgical Oncology, 71
F. Geyer, B. Weigelt, R. Natrajan, Maryou Lambros, D. Biase, R. Vatcheva, K. Savage, A. Mackay, A. Ashworth, J. Reis-Filho (2010)
Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomasThe Journal of Pathology, 220
S. Leibl, Margit Gogg-Kammerer, Andrea Sommersacher, H. Denk, F. Moinfar (2005)
Metaplastic Breast Carcinomas: Are They of Myoepithelial Differentiation?: Immunohistochemical Profile of the Sarcomatoid Subtype Using Novel Myoepithelial MarkersThe American Journal of Surgical Pathology, 29
Metaplastic breast carcinoma (MBC) is a heterogenous group of tumors that diverge from conventional glandular differentiation. The metaplastic component can be focal or may be present purely posing diagnostic challenges. Since MBC may show focal immunostaining or may even be negative for some cytokeratins (CK), different CKs are often needed to prove their epithelial origin. OSCAR is a relatively new broad-spectrum anti-CK antibody. Thirty MBC cases diagnosed at our institution were retrieved, including 7 spindle cell carcinomas. Representative slides were immunostained for CK-OSCAR, CK-AE1/AE3, CAM5.2, CK-903, and CK5/6. Nineteen spindle cell lesions were used as controls, including 6 malignant and 10 borderline phyllodes tumor, 1 inflammatory pseudotumor, 1 solitary fibrous tumor, and 1 nodular fasciitis case. All 30 cases (100%) of metaplastic carcinomas were positive for CK-OSCAR, compared with 27/30 (90%, P=0.076) for CK-AE1/AE3, 21/30 (70%, P≤0.01) for CK-903, 19/30 (63.3%, P≤0.01) for CAM5.2, and 15/30 (50%, P≤0.01) for CK5/6. All control cases were negative for CK-OSCAR. All 7 spindle cell carcinomas were also positive for CK-OSCAR (100%) compared with 6/7 (85.7%) for CK-AE1/AE3, 4/7 (57%) for CK-903, 3/7 (42.8%) for CAM5.2, and 2/7 (28.5%) for CK5/6. Our data show that CK-OSCAR is more sensitive than other individual CKs in diagnosing MBC. Coupled with high specificity, CK-OSCAR may potentially be used in lieu of a panel of CKs to identify the epithelial origin of these tumors, especially in spindle cell tumors. This is particularly useful in limited core biopsy specimens, to help guide treatment and simultaneously lower testing costs.
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Oct 1, 2016
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.