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ORIGINAL ARTICLE Diagnosis of Mediastinal Adenopathy—Real-Time Endobronchial Ultrasound Guided Needle Aspiration versus Mediastinoscopy Armin Ernst, MD, FCCP,*† Devanand Anantham, MRCP,‡ Ralf Eberhardt, MD,† Mark Krasnik, MD,§ and Felix J. F. Herth, MD, FCCP† Conclusions: In suspected nonsmall cell lung cancer, endobronchial Background: Real-time endobronchial ultrasound has increased the ultrasound may be preferred in the histologic sampling of paratra- accuracy of conventional transbronchial needle aspiration biopsy in cheal and subcarinal mediastinal adenopathy because the diagnostic sampling mediastinal lymph nodes. Nevertheless, direct compari- yield can surpass mediastinoscopy. sons with mediastinoscopy are not available to determine the role of Key Words: Endobronchial ultrasound, Cervical mediastinoscopy, endobronchial ultrasound in pathologic staging. Nonsmall cell lung cancer, Transbronchial needle aspiration, Medi- Objectives: To compare the diagnostic yield of endobronchial astinal lymph nodes. ultrasound against cervical mediastinoscopy in the diagnosis and staging of radiologically enlarged mediastinal lymph nodes stations (J Thorac Oncol. 2008;3: 577–582) accessible by both modalities in patients with suspected nonsmall cell lung cancer. Methods: Prospective, crossover trial with surgical lymph node ccurate staging of the mediastinum is essential to evaluate dissection used as the accepted standard. Biopsy results of paratra- Aprognosis in nonsmall cell lung cancer and to devise an cheal and subcarinal
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Jun 1, 2008
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