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ORIGINAL ARTICLE Dexamethasone and Salbutamol Stimulate Human Lung Fibroblast Proliferation 1 2 3 4 Eran Pickholtz, MD, Dan Admon, MD, Uzi Izhar, MD, Neville Berkman, MBBCh, FRCP, and Francesca Levi-Schaffer, RPh, PhD Remodeling features are damage and shedding of airway Background: Asthma is characterized by bronchial hyperreactivity epithelium, increased number of goblet cells, mucous gland and airway remodeling. Subepithelial fibrosis, a feature of remodel- hypertrophy, increased fibroblast/myofibroblast numbers, and ing, is accompanied by activation of fibroblasts to myofibroblasts, 1–3 increased airway smooth muscle mass and neovascularity. with excessive proliferation and increased collagen, extracellular Fibroblasts are thought to play a major role in the development matrix protein, and profibrogenic cytokine production. Mast cells are of the structural changes in the airways by altering their phe- important in the development of asthma and its fibrotic changes. notype from a quiescent cell into a-actin containing myofibro- Objective: In this study, we aimed to investigate the direct effect of blasts that display enhanced proliferation, increased collagen the drugs most frequently used in asthma, that is, glucocorticoste- and other extracellular matrix protein production, expression of roids (dexamethasone) and shortacting b -agonists (salbutamol), on adhesion molecules, and production of profibrotic and proin- human lung fibroblast
World Allergy Organization Journal – Wolters Kluwer Health
Published: Dec 1, 2011
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