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REVIEW ARTICLE Detection of EGFR-TK Domain–activating Mutations in NSCLC With Generic PCR-based Methods Rajendra B. Shahi, MSc,* Sylvia De Brakeleer, MSc,* Jacques De Gre`ve, MD, PhD,* Caroline Geers, MD,w Peter In’t Veld, PhD,w and Erik Teugels, PhD* pidermal growth factor receptor (EGFR), the mam- Abstract: Somatic mutations in the epidermal growth factor Emalian homolog of avian viral oncoprotein v-erbB, is a receptor-tyrosine kinase (EGFR-TK) domain of non–small cell member of the ErbB family found normally on the surface lung cancer (NSCLC) influence the responsiveness of these tu- of the epithelial cells and is responsible for the regulation mors to EGFR-TK inhibitors, indicating their usefulness as a of a number of cellular processes such as proliferation, 1–4 predictive molecular marker. However, for mutation analysis, motility, and survival. Mutation of the EGFR gene in the amount of clinical material available from NSCLC patients non–small cell lung cancer (NSCLC) is considered to be is often very limited, suboptimally preserved, and composed of an indicator for differential clinical responses to reversible both normal and tumor cells. As a consequence, the total tyrosine kinase (TK) inhibitors such as gefitinib and 5–7 amount of recovered DNA is frequently very limited, with erlotinib. Therefore, the screening
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Mar 1, 2015
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