Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
a,b,c Mariana Castells Purpose of review Introduction Desensitization for drug allergy is the induction of temporary The development of rapid desensitizations for the treat- clinical unresponsiveness to drug antigens. Gradual ment of drug hypersensitivities is aimed at providing reintroduction of small doses of drug antigen at fixed time essential medications while protecting patients from intervals allows for the delivery of full therapeutic doses, severe reactions induced by anaphylactic and anaphylac- protecting patients from anaphylaxis. Rapid toid mechanisms. Serious adverse drug reactions occur in desensitizations permit the use of essential antibiotics in 6.7% of hospitalized patients, and adverse drug reactions severely infected allergic patients or aspirin in aspirin- are the fourth to sixth leading cause of death in such sensitive cardiac patients undergoing revascularization. We patients [1]. Drug-induced type I hypersensitivity reac- review the indications and outcomes of recent protocols for tions, such as anaphylaxis, result from the release of desensitization to antibiotics and aspirin. mediators from IgE-sensitized mast cells or basophils. Recent findings Drug-associated anaphylaxis can be triggered by b-lac- Despite the success of rapid desensitizations, the cellular tam antibiotics, such as penicillin and cephalosporins, and molecular inhibitory mechanisms are incompletely chemotherapy drugs, such as platins, therapeutic mono- understood.
Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health
Published: Dec 1, 2006
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.