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Desensitization for drug allergy

Desensitization for drug allergy a,b,c Mariana Castells Purpose of review Introduction Desensitization for drug allergy is the induction of temporary The development of rapid desensitizations for the treat- clinical unresponsiveness to drug antigens. Gradual ment of drug hypersensitivities is aimed at providing reintroduction of small doses of drug antigen at fixed time essential medications while protecting patients from intervals allows for the delivery of full therapeutic doses, severe reactions induced by anaphylactic and anaphylac- protecting patients from anaphylaxis. Rapid toid mechanisms. Serious adverse drug reactions occur in desensitizations permit the use of essential antibiotics in 6.7% of hospitalized patients, and adverse drug reactions severely infected allergic patients or aspirin in aspirin- are the fourth to sixth leading cause of death in such sensitive cardiac patients undergoing revascularization. We patients [1]. Drug-induced type I hypersensitivity reac- review the indications and outcomes of recent protocols for tions, such as anaphylaxis, result from the release of desensitization to antibiotics and aspirin. mediators from IgE-sensitized mast cells or basophils. Recent findings Drug-associated anaphylaxis can be triggered by b-lac- Despite the success of rapid desensitizations, the cellular tam antibiotics, such as penicillin and cephalosporins, and molecular inhibitory mechanisms are incompletely chemotherapy drugs, such as platins, therapeutic mono- understood. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Allergy and Clinical Immunology Wolters Kluwer Health

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ISSN
1528-4050
eISSN
1473-6322
DOI
10.1097/ACI.0b013e3280108716
pmid
17088655
Publisher site
See Article on Publisher Site

Abstract

a,b,c Mariana Castells Purpose of review Introduction Desensitization for drug allergy is the induction of temporary The development of rapid desensitizations for the treat- clinical unresponsiveness to drug antigens. Gradual ment of drug hypersensitivities is aimed at providing reintroduction of small doses of drug antigen at fixed time essential medications while protecting patients from intervals allows for the delivery of full therapeutic doses, severe reactions induced by anaphylactic and anaphylac- protecting patients from anaphylaxis. Rapid toid mechanisms. Serious adverse drug reactions occur in desensitizations permit the use of essential antibiotics in 6.7% of hospitalized patients, and adverse drug reactions severely infected allergic patients or aspirin in aspirin- are the fourth to sixth leading cause of death in such sensitive cardiac patients undergoing revascularization. We patients [1]. Drug-induced type I hypersensitivity reac- review the indications and outcomes of recent protocols for tions, such as anaphylaxis, result from the release of desensitization to antibiotics and aspirin. mediators from IgE-sensitized mast cells or basophils. Recent findings Drug-associated anaphylaxis can be triggered by b-lac- Despite the success of rapid desensitizations, the cellular tam antibiotics, such as penicillin and cephalosporins, and molecular inhibitory mechanisms are incompletely chemotherapy drugs, such as platins, therapeutic mono- understood.

Journal

Current Opinion in Allergy and Clinical ImmunologyWolters Kluwer Health

Published: Dec 1, 2006

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