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Definition, etiology, and diagnosis of food protein-induced enterocolitis syndrome

Definition, etiology, and diagnosis of food protein-induced enterocolitis syndrome REVIEW URRENT Definition, etiology, and diagnosis of food PINION protein-induced enterocolitis syndrome Elizabeth Feuille and Anna Nowak-We˛grzyn Purpose of review Food protein-induced enterocolitis syndrome (FPIES) is a poorly understood non-IgE-mediated food hypersensitivity, primarily affecting infants and toddlers. There are few data regarding pathophysiology of FPIES that suggest local intestinal imbalance between TNF-a and TGF-b. Patients frequently present with multiple reactions, which are characterized by projectile, repetitive emesis, dehydration, lethargy, and failure to thrive. Despite the severity of presentation, the diagnosis is frequently delayed, and patients often undergo extensive and invasive evaluation prior to reaching the diagnosis. Recent findings Reviews published in the last year provide a general approach to diagnosis and management of FPIES and aim to increase awareness and understanding of FPIES among general pediatricians. Summary Multicenter studies are necessary to reevaluate and modify the oral food challenge criteria. Research on the pathophysiology of FPIES reactions is necessary to provide insight into the evidence-based approach to diagnosis and management of FPIES. Registries are needed to understand the phenotype, triggers, and prevalence of FPIES. Keywords allergic enterocolitis, food allergy, food protein-induced enterocolitis syndrome INTRODUCTION HISTORICAL PERSPECTIVE Food protein-induced enterocolitis syndrome In 1940, Rubin [3] reported intestinal bleeding due (FPIES) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Allergy and Clinical Immunology Wolters Kluwer Health

Definition, etiology, and diagnosis of food protein-induced enterocolitis syndrome

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Copyright
© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins
ISSN
1528-4050
eISSN
1473-6322
DOI
10.1097/ACI.0000000000000055
pmid
24686276
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Abstract

REVIEW URRENT Definition, etiology, and diagnosis of food PINION protein-induced enterocolitis syndrome Elizabeth Feuille and Anna Nowak-We˛grzyn Purpose of review Food protein-induced enterocolitis syndrome (FPIES) is a poorly understood non-IgE-mediated food hypersensitivity, primarily affecting infants and toddlers. There are few data regarding pathophysiology of FPIES that suggest local intestinal imbalance between TNF-a and TGF-b. Patients frequently present with multiple reactions, which are characterized by projectile, repetitive emesis, dehydration, lethargy, and failure to thrive. Despite the severity of presentation, the diagnosis is frequently delayed, and patients often undergo extensive and invasive evaluation prior to reaching the diagnosis. Recent findings Reviews published in the last year provide a general approach to diagnosis and management of FPIES and aim to increase awareness and understanding of FPIES among general pediatricians. Summary Multicenter studies are necessary to reevaluate and modify the oral food challenge criteria. Research on the pathophysiology of FPIES reactions is necessary to provide insight into the evidence-based approach to diagnosis and management of FPIES. Registries are needed to understand the phenotype, triggers, and prevalence of FPIES. Keywords allergic enterocolitis, food allergy, food protein-induced enterocolitis syndrome INTRODUCTION HISTORICAL PERSPECTIVE Food protein-induced enterocolitis syndrome In 1940, Rubin [3] reported intestinal bleeding due (FPIES)

Journal

Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health

Published: Jun 1, 2014

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