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De Novo Acute Myeloid Leukemia in Adults Suppression of MicroRNA-223 is Independent of LMO2 Protein Expression BUT

De Novo Acute Myeloid Leukemia in Adults Suppression of MicroRNA-223 is Independent of LMO2... RESEARCH ARTICLE De Novo Acute Myeloid Leukemia in Adults: Suppression of MicroRNA-223 is Independent of LMO2 Protein Expression BUT Associate With Adverse Cytogenetic Profile and Undifferentiated Blast Morphology Ariz Akhter, PhD,* Jay L. Patel, FRCPC,* Fahad Farooq, BSc,* Abid Qureshi, BSc,* Meer-Shahbani Taher-Rad, FRCPC,* Ghaleb Elyamany, FRCPC,w Ali M. Al-Zahrani, FRCR,w Fariborz Rashid-Kolvear, PhD,z and Adnan Mansoor, FRCPC* that suppression of MIR223 expression, as compared with Abstract: MicroRNA (MIR) signatures are critical to pathobi- controls, is associated with lack of differentiation and adverse ology and prognosis of acute myeloid leukemia (AML). cytogenetic profile, but unrelated with LMO2 protein expression MIR223 is expressed at low levels in progenitor cells, whereas or overall survival. high expression is induced by granulocytic differentiation. Key Words: acute myeloid leukemia, microRNA, MIR223, Novel-targeted therapies through epigenetic manipulation of LMO2 protein, cytogenetic risk groups, AML-NOS with dif- MIR223 regulators are being explored in AML but correlative ferentiation, WHO classification, FAB classification data between established clinical prognostic markers and MIR223 expression in AML is lacking. MIR223 has inverse relationship (Appl Immunohistochem Mol Morphol 2015;00:000–000) with LMO2 protein expression and our group has recently reported a close association between LMO2 protein expression and chro- mosomal findings in AML http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

De Novo Acute Myeloid Leukemia in Adults Suppression of MicroRNA-223 is Independent of LMO2 Protein Expression BUT

Mansoor, Adnan
Applied Immunohistochemistry & Molecular Morphology , Volume Publish Ahead of Print – Feb 1, 2015
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Copyright
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1541-2016
DOI
10.1097/PAI.0000000000000145
pmid
25710580
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE De Novo Acute Myeloid Leukemia in Adults: Suppression of MicroRNA-223 is Independent of LMO2 Protein Expression BUT Associate With Adverse Cytogenetic Profile and Undifferentiated Blast Morphology Ariz Akhter, PhD,* Jay L. Patel, FRCPC,* Fahad Farooq, BSc,* Abid Qureshi, BSc,* Meer-Shahbani Taher-Rad, FRCPC,* Ghaleb Elyamany, FRCPC,w Ali M. Al-Zahrani, FRCR,w Fariborz Rashid-Kolvear, PhD,z and Adnan Mansoor, FRCPC* that suppression of MIR223 expression, as compared with Abstract: MicroRNA (MIR) signatures are critical to pathobi- controls, is associated with lack of differentiation and adverse ology and prognosis of acute myeloid leukemia (AML). cytogenetic profile, but unrelated with LMO2 protein expression MIR223 is expressed at low levels in progenitor cells, whereas or overall survival. high expression is induced by granulocytic differentiation. Key Words: acute myeloid leukemia, microRNA, MIR223, Novel-targeted therapies through epigenetic manipulation of LMO2 protein, cytogenetic risk groups, AML-NOS with dif- MIR223 regulators are being explored in AML but correlative ferentiation, WHO classification, FAB classification data between established clinical prognostic markers and MIR223 expression in AML is lacking. MIR223 has inverse relationship (Appl Immunohistochem Mol Morphol 2015;00:000–000) with LMO2 protein expression and our group has recently reported a close association between LMO2 protein expression and chro- mosomal findings in AML

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Feb 1, 2015

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