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RESEARCH ARTICLE Cyclin D1 Expression in Benign and Differentiated Malignant Tumors of the Thyroid Gland: Diagnostic and Biologic Implications Timothy P. Seybt, MD,* Preetha Ramalingam, MBBS,* Jie Huang, MS,w Stephen W. Looney, PhD,w and Michelle D. Reid, MBBS* linically detectable thyroid nodules occur in up to Abstract: Cyclin D1 expression was examined in benign and C10% of the population; however, only 5% of these differentiated malignant thyroid tumors to determine diagnostic are malignant. Fine needle aspiration serves a critical role utility and correlation with tumor type, size, and nodal status; as a screening tool in the presurgical evaluation of these 29 follicular adenomas (FA), 23 follicular carcinomas (FCA) nodules but it has variable sensitivity and specificity. The and 43 papillary thyroid carcinomas (PTC) (22 with and 21 gold standard for diagnosis of thyroid tumors is without nodal metastases) were stained. PTCs included 27 histologic evaluation of the excised nodule. Accurate classical (PTCC) and 16 follicular variants (PTCFV). A statis- distinction between benign and malignant thyroid tumors tically significant association was found between tumor type has crucial therapeutic implications. However, histologic and cyclin D1 staining, distribution, and intensity. There were diagnosis of papillary and follicular carcinoma (FCA), fewer cyclin D1-positive
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Mar 1, 2012
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