Access the full text.
Sign up today, get DeepDyve free for 14 days.
Statistical significance of metabolic data were analyzed by using two-tailed unpaired Student's t test
S. Long, J. Buckner (2011)
CD4+FOXP3+ T Regulatory Cells in Human Autoimmunity: More Than a Numbers GameThe Journal of Immunology, 187
Liping Liu, M. Callahan, Deren Huang, R. Ransohoff (2005)
Chemokine receptor CXCR3: an unexpected enigma.Current topics in developmental biology, 68
V. Rocha, E. Folco (2011)
Inflammatory Concepts of ObesityInternational Journal of Inflammation, 2011
M. Gregor, G. Hotamışlıgil (2011)
Inflammatory mechanisms in obesity.Annual review of immunology, 29
S. Nishimura, I. Manabe, M. Nagasaki, K. Eto, H. Yamashita, M. Ohsugi, M. Otsu, K. Hara, K. Ueki, S. Sugiura, K. Yoshimura, T. Kadowaki, R. Nagai (2009)
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesityNature Medicine, 15
V. Appay, S. Rowland-Jones (2001)
RANTES: a versatile and controversial chemokine.Trends in immunology, 22 2
Joanne, L., Whiteland, Susan Nicholls, C. Shimeld, David, Easty, Neil Williams, Terry, J., Hill (1995)
Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 43
S. Weisberg, D. McCann, M. Desai, M. Rosenbaum, R. Leibel, A. Ferrante (2003)
Obesity is associated with macrophage accumulation in adipose tissue.The Journal of clinical investigation, 112 12
N. Veillard, S. Steffens, G. Pelli, Bao Lu, B. Kwak, C. Gerard, I. Charo, F. Mach (2005)
Differential Influence of Chemokine Receptors CCR2 and CXCR3 in Development of Atherosclerosis In VivoCirculation, 112
F. Mach, A. Sauty, Albert Iarossi, G. Sukhova, K. Neote, P. Libby, A. Luster (1999)
Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells.The Journal of clinical investigation, 104 8
All p values ≤ 0.05 were considered statistically significant
S. Weisberg, Deborah Hunter, R. Huber, Jacob Lemieux, S. Slaymaker, K. Vaddi, I. Charo, R. Leibel, A. Ferrante (2006)
CCR2 modulates inflammatory and metabolic effects of high-fat feeding.The Journal of clinical investigation, 116 1
M. Pfaffl, G. Horgan, L. Dempfle (2002)
Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR.Nucleic acids research, 30 9
E. Wanrooij, S. Jager, T. Es, P. Vos, H. Birch, D. Owen, R. Watson, E. Biessen, G. Chapman, T. Berkel, J. Kuiper (2007)
CXCR3 Antagonist NBI-74330 Attenuates Atherosclerotic Plaque Formation in LDL Receptor–Deficient MiceArteriosclerosis, Thrombosis, and Vascular Biology, 28
Huaizhu Wu, S. Ghosh, X. Perrard, Lili Feng, G. Garcia, J. Perrard, J. Sweeney, Leif Peterson, L. Chan, C. Smith, C. Ballantyne (2007)
T-Cell Accumulation and Regulated on Activation, Normal T Cell Expressed and Secreted Upregulation in Adipose Tissue in ObesityCirculation, 115
P. Nishina, Jiajin Wang, W. Toyofuku, F. Kuypers, B. Ishida, B. Paigen (1993)
Atherosclerosis and plasma and liver lipids in nine inbred strains of miceLipids, 28
M. Ruth (2010)
Normalization of obesity-associated insulin resistance through immunotherapyYearbook of Endocrinology, 2010
BMI, cell counts, and plasma measurements) were compared between CXCR3- deficient mice and respective controls with the two-tailed, unpaired Student's t- test
Hajime Kanda, Sanshiro Tateya, Y. Tamori, K. Kotani, K. Hiasa, R. Kitazawa, S. Kitazawa, Hitoshi Miyachi, S. Maeda, K. Egashira, M. Kasuga (2006)
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity.The Journal of clinical investigation, 116 6
H. Kang, Cafer Ozdemir, Y. Kawano, Katherine LeClair, C. Vernochet, C. Kahn, S. Hagen, D. Cohen (2013)
Thioesterase Superfamily Member 2/Acyl-CoA Thioesterase 13 (Them2/Acot13) Regulates Adaptive Thermogenesis in Mice*The Journal of Biological Chemistry, 288
N. Platt, Hiroshi Suzuki, Y. Kurihara, Tatsuhiko Kodama, S. Gordon (1996)
Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro.Proceedings of the National Academy of Sciences of the United States of America, 93 22
Interferon- (cid:1) , a Th1 Cytokine, Regulates Fat Inflammation A Role for Adaptive Immunity in Obesity
V. Bronte, P. Serafini, A. Mazzoni, D. Segal, P. Zanovello (2003)
L-arginine metabolism in myeloid cells controls T-lymphocyte functions.Trends in immunology, 24 6
Haiyan Xu, Glenn Barnes, Qing Yang, G. Tan, Daseng Yang, C. Chou, Jason Sole, A. Nichols, J. Ross, L. Tartaglia, Hong Chen (2003)
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.The Journal of clinical investigation, 112 12
Mayoura Kéophiphath, C. Rouault, A. Divoux, K. Clément, D. Lacasa (2010)
CCL5 Promotes Macrophage Recruitment and Survival in Human Adipose TissueArteriosclerosis, Thrombosis, and Vascular Biology, 30
C. Lumeng, Jennifer Bodzin, A. Saltiel (2007)
Obesity induces a phenotypic switch in adipose tissue macrophage polarization.The Journal of clinical investigation, 117 1
U. Kintscher, M. Hartge, K. Hess, A. Foryst-Ludwig, M. Clemenz, M. Wabitsch, P. Fischer-Posovszky, T. Barth, D. Dragun, T. Skurk, H. Hauner, M. Blüher, T. Unger, A. Wolf, U. Knippschild, V. Hombach, N. Marx (2008)
T-lymphocyte Infiltration in Visceral Adipose Tissue: A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin ResistanceArteriosclerosis, Thrombosis, and Vascular Biology, 28
W. Hancock, B. Lu, Wei Gao, V. Csizmadia, K. Faia, J. King, S. Smiley, Mai Ling, N. Gerard, C. Gerard (2000)
Requirement of the Chemokine Receptor CXCR3 for Acute Allograft RejectionThe Journal of Experimental Medicine, 192
S. Gordon (2003)
Alternative activation of macrophagesNature Reviews Immunology, 3
E. Heller, E. Liu, A. Tager, Q. Yuan, Alexander Lin, N. Ahluwalia, K. Jones, Stephanie Koehn, Vincent Lok, E. Aikawa, K. Moore, A. Luster, R. Gerszten (2006)
Chemokine CXCL10 Promotes Atherogenesis by Modulating the Local Balance of Effector and Regulatory T CellsCirculation, 113
Beverly Paigen, P. Holmes, D. Mitchell, D. Albee (1987)
Comparison of atherosclerotic lesions and HDL-lipid levels in male, female, and testosterone-treated female mice from strains C57BL/6, BALB/c, and C3H.Atherosclerosis, 64 2-3
Y. Okamoto, E. Folco, M. Minami, A. Wara, M. Feinberg, G. Sukhova, R. Colvin, S. Kihara, T. Funahashi, A. Luster, P. Libby (2008)
Adiponectin Inhibits the Production of CXC Receptor 3 Chemokine Ligands in Macrophages and Reduces T-Lymphocyte Recruitment in AtherogenesisCirculation Research, 102
Soo Lim, J. Meigs (2013)
Ectopic fat and cardiometabolic and vascular risk.International journal of cardiology, 169 3
M. Feuerer, Laura Herrero, D. Cipolletta, A. Naaz, J. Wong, A. Nayer, Jongsoon Lee, A. Goldfine, C. Benoist, S. Shoelson, D. Mathis (2009)
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parametersNature Medicine, 15
GGCTGGAGAGCTACAAGAGG-3' 5'-TCTTGAGCTTGGTGACAAAAAC-3' RANTES 5'-AGCAGCAAGTGCTCCAATC-3' 5'-GGGAAGCGTATACAGGGTC-3' IFN-γ 5
Viviane Zorzanelli Rocha, Eduardo J. Folco, Cafer Ozdemir, Yuri Sheikine, Thomas Christen, Galina K. Sukhova, Eva H.C. Tang, Marcio Sommer Bittencourt, Raul D. Santos, Andrew D. Luster, David E. Cohen, Peter Libby Objective—Obesity associates with increased numbers of inflammatory cells in adipose tissue (AT), including T cells, but the mechanism of T-cell recruitment remains unknown. This study tested the hypothesis that the chemokine (C-X-C motif) receptor 3 (CXCR3) participates in T-cell accumulation in AT of obese mice and thus in the regulation of local inflammation and systemic metabolism. Approach and Results—Obese wild-type mice exhibited higher mRNA expression of CXCR3 in periepididymal AT-derived stromal vascular cells compared with lean mice. We evaluated the function of CXCR3 in AT inflammation in vivo using CXCR3-deficient and wild-type control mice that consumed a high-fat diet. Periepididymal AT from obese CXCR3- deficient mice contained fewer T cells than obese controls after 8 and 16 weeks on high-fat diet, as assessed by flow cytometry. Obese CXCR3-deficient mice had greater glucose tolerance than obese controls after 8 weeks, but not after 16 weeks. CXCR3-deficient mice fed high-fat diet had reduced mRNA expression of proinflammatory mediators, such as monocyte chemoattractant protein-1 and regulated on activation, normal T
Arteriosclerosis, Thrombosis, and Vascular Biology – Wolters Kluwer Health
Published: Jul 1, 2014
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.